PromAce (acepromazine) 10mg, 100 tablets

Precise Low-Dose Phenothiazine Tranquilizer Tablet for Small Dogs and Sensitive Patients

Product Description

PromAce (Acepromazine Maleate) Tablets 10 mg are FDA-approved prescription phenothiazine neuroleptic tablets for use in dogs only. Each quarter-scored tablet contains 10 mg acepromazine maleate — the lower-strength option in the PromAce tablet line, offering finer dose control for small breeds, dogs requiring a conservative starting dose, or patients where titration in smaller increments is clinically appropriate. Acepromazine produces its effects through central nervous system depression, resulting in sedation, muscle relaxation, and decreased spontaneous movement via dopamine receptor blockade. Indicated as an aid in canine tranquilization and as a preanesthetic agent, and useful for managing difficult-to-handle dogs during clinical procedures. Supplied in bottles of 100 tablets.

Benefits

• Dose Control: The 10 mg strength allows 2.5 mg increments when quarter-scored, suitable for small dogs.
• Preanesthetic Use: It reduces total general anesthetic requirements in dogs, supporting safer induction and smoother perioperative management.
• Rapid Calming: Acepromazine provides rapid calming without hypnosis, keeping the dog responsive during examination or treatment procedures.
• Muscle Relaxation: It produces sedation with muscle relaxation, helping reduce resistance and physical tension during veterinary procedures.
• Low Toxicity Profile: Both acute and chronic toxicity studies confirmed a very low order of toxicity for acepromazine maleate in dogs at recommended doses.
• Repeatable Dosing as Needed: The tablet dose may be repeated as required based on the dog's clinical response and duration of procedure, under veterinary direction.

Ingredients

Active Ingredients

Acepromazine Maleate: 10 mg per tablet

How to Use

Dosage and Administration Instructions

• Prescription Required: Federal law restricts PromAce Tablets to use by or on the order of a licensed veterinarian only.
• For Dogs Only: PromAce 10 mg Tablets are approved for use in dogs only; do not give to cats, horses, or any other species.
• Oral Dose Range: Administer 0.25 to 1.0 mg per lb of body weight orally; always begin at the lowest end of the range and adjust upward only under veterinary direction.
• Quarter-Score for Small-Dog Dosing: The 10 mg tablet can be split into four 2.5 mg pieces along the score lines, enabling very precise weight-based dosing in toy and small breeds.
• Administer 45-60 Minutes Before Procedure: Give the tablet roughly 45 to 60 minutes before the examination or clinical event to allow the full sedative effect to develop before it is needed.
• Dose Can Be Repeated: The dose may be repeated as clinically required; consult the prescribing veterinarian before repeating to confirm timing and appropriateness.
• Lower Starting Dose in Sensitive Patients: For dogs that are stressed, hypovolemic, debilitated, in shock, or have cardiac disease, begin at the very bottom of the dose range and monitor closely.
• Monitor Throughout Full Duration: Since no reversal agent exists for acepromazine, keep the dog under close observation for the entire sedation period, which typically lasts 6-8 hours.

Disclaimer: This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any supplement for your pet.

Additional Information

Precautions

• Organophosphate Contraindication: Never use PromAce alongside organophosphate-based dewormers, ectoparasiticides, or flea collars; phenothiazines significantly increase organophosphate toxicity.
• Procaine Hydrochloride Contraindication: Do not administer PromAce together with procaine hydrochloride under any circumstances due to the risk of a serious drug interaction.
• Epinephrine Contraindicated: Administering epinephrine to an acepromazine-treated dog causes a dangerous paradoxical blood pressure drop; never use these two drugs together.
• Additive with CNS Depressants: PromAce potentiates all other CNS depressants; doses of concurrently used sedatives, anesthetics, or tranquilizers must be reduced accordingly.
• Sighthound and Giant Breed Sensitivity: Greyhounds, other sighthounds, and giant breeds may experience prolonged or exaggerated effects; veterinary supervision is especially important in these dogs.
• MDR1 Mutation Caution: Breeds prone to the MDR1 gene mutation (such as Collies and Australian Shepherds) show heightened sensitivity to acepromazine; only the lowest effective dose should be used.
• Liver Disease Prolongs Effect: Dogs with impaired liver function metabolize acepromazine more slowly; sedation may last significantly longer than expected and requires closer monitoring.
• Keep Out of Reach: Store in a locked location away from children and all animals to prevent any accidental access or ingestion.

Possible Side Effects

• Mild and Transient Depression: Safety studies at elevated doses found the sole consistent observation was mild depression, which resolved in most dogs within 24 hours of stopping acepromazine.
• Brief Reverse Sneeze: The only adverse reaction observed across numerous clinical trials was a transient, mild reverse sneeze that had no impact on the drug's therapeutic effect.
• Rare Idiosyncratic Behavioral Reactions: Uncommonly, dogs have developed unexpected aggression, biting or chewing behavior, and agitation following acepromazine administration rather than sedation.
• Prolonged Sedation in Sensitive Dogs: Older dogs, those with liver or kidney disease, and giant breeds may experience sedation lasting beyond 12 hours; monitor until the dog is fully ambulatory.
• Motor Restlessness: Rather than calming, some dogs given excessive doses develop motor restlessness; if this occurs, stop further dosing and monitor the dog in a safe environment.

Storage Information

• Room Temperature Storage: Store at 20-25°C (68-77°F); excursions between 15-30°C (59-86°F) are permitted without impact on tablet stability or potency.
• Secure from All Pets and Children: Keep in a locked location inaccessible to dogs, cats, and children; acepromazine is a potent CNS-active agent that poses serious risk if accidentally ingested.

Shipping & Return

We offer ground, express, and priority delivery; see our shipping policy for details.

For return instructions or product concerns, please refer to our detailed refund policy.

Prescription items are NON-RETURNABLE and NON-REFUNDABLE.

Frequently Asked Questions

Q1: What is PromAce 10 mg acepromazine used for in dogs?

Ans: PromAce 10 mg Tablets are FDA-approved for dogs as a tranquilizing and preanesthetic agent. The 10 mg strength is particularly well suited to small breeds, dogs needing a conservative starting dose, or situations where precise dose titration in smaller increments is required for safe and effective sedation.

Q2: Why would a vet choose the 10 mg PromAce tablet over the 25 mg tablet?

Ans: The 10 mg tablet is preferred for small dogs where the 25 mg tablet would be too strong even when halved, for patients with liver disease or other sensitivity concerns requiring a more cautious approach, and when the veterinarian wants to begin at the very lowest end of the dose range with the ability to fine-tune in 2.5 mg quarter-scored increments.

Q3: Does acepromazine PromAce relieve pain in dogs?

Ans: No. Acepromazine is a tranquilizer and neuroleptic agent — it produces sedation and muscle relaxation but has no analgesic properties. It does not relieve pain on its own. When pain management is needed alongside sedation, a separate analgesic must be prescribed and administered by the veterinarian.

Q4: Can PromAce 10 mg acepromazine tablets be given to cats?

Ans: No. PromAce Tablets in both the 10 mg and 25 mg strengths are FDA-approved for use in dogs only. While acepromazine injectable solution is used in cats and horses by veterinarians, the tablet form carries a dogs-only label. Never administer the tablet to cats without specific veterinary instruction, as this would constitute off-label use.

Q5: What happens if a dog wearing a flea collar is given PromAce acepromazine tablets?

Ans: This combination is explicitly contraindicated. Phenothiazine drugs like acepromazine potentiate the toxicity of organophosphate compounds found in many flea collars. Giving acepromazine to a dog wearing an organophosphate flea collar can result in serious toxic reactions. Remove all organophosphate-containing products and inform the vet before any acepromazine treatment is given.