Revolution for Cats 5.1-15 lbs

Zoetis SKU: 10000335-1


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Revolution for Cats 5.1-15 lbs

Revolution is a medication that is applied directly to your furry friend's skin to protect them from biting critters. When applied every 30 days, Revolution protects against heartworms and fleas. It may also be effective in preventing and treating ear mites, roundworms, and hookworms.


  • 5-in-1 parasite protection
  • Veterinarians' #1 choice for cats
  • 20+ Years of proven safety
  • No separation from family after application
  • Non-greasy, easy to apply

Prescription items are NON-RETURNABLE and NON-REFUNDABLE.

Please note product may arrive in a Hardy Paw Pharmacy vial, manufacturer packaging is shown for reference.

Possible Side Effects

The most common is hair loss at the site of application with or without inflammation (redness, flaking) in cats. Other side effects reported in cats and dogs include vomiting, diarrhea with or without blood, anorexia (decreased appetite), lethargy (sluggishness), salivation, rapid breathing, pruritus (itching), urticaria (welts, hives), erythema (skin redness), ataxia (incoordination), fever and rare instances of death. There have also been rare reports of seizures in dogs. If you have additional questions about possible side effects, talk to your veterinarian.


The recommended minimum dose is 2.7 mg selamectin per pound (6 mg/kg) of body weight.

Administer the entire contents of a single dose tube (or two tubes used in combination for dogs weighing over 130 pounds) of Revolution topically in accordance with the following tables.

Cats (lb) Package color mg per tube Potency (mg/mL) Administered volume (mL)
Up to 5 Mauve 15 mg 60 0.25
5.1 - 15 Blue 45 mg 60 0.75
15.1 - 22 Taupe 60 mg 60 1.0

For cats over 22 lbs use the appropriate combination of tubes.

A veterinarian or veterinary technician should demonstrate or instruct the pet owner regarding the appropriate technique for applying Revolution topically to dogs and cats prior to first use.

revolution for cats application

Firmly press the cap down to puncture the seal on the Revolution tube; a clicking sound will confirm that the cap has successfully punctured the seal. Remove the cap and check to ensure that the tip of the tube is open. To administer the product, part the hair on the back of the animal at the base of the neck in front of the shoulder blades until the skin is visible. Place the tip of the tube on the skin and squeeze the tube 3 or 4 times to empty its entire contents directly onto the skin in one spot. Keeping the tube squeezed, drag it away from the liquid and lift to remove. Check the tube to ensure that it is empty. Do not massage the product into the skin. Due to alcohol content, do not apply to broken skin. Avoid contact between the product and fingers. Do not apply when the haircoat is wet. Bathing or shampooing the dog 2 or more hours after treatment will not reduce the effectiveness of Revolution against fleas or heartworm. Bathing or shampooing the cat 2 hours after treatment will not reduce the effectiveness of Revolution against fleas. Bathing or shampooing the cat 24 hours after treatment will not reduce the effectiveness of Revolution against heartworm. Stiff hair, clumping of hair, hair discoloration, or a slight powdery residue may be observed at the treatment site in some animals. These effects are temporary and do not affect the safety or effectiveness of the product. Discard empty tubes in your ordinary household refuse.

Flea Control in Dogs and Cats

For the prevention and control of flea infestations, Revolution should be administered at monthly intervals throughout the flea season, starting one month before fleas become active. In controlled laboratory studies ›98% of fleas were killed within 36 hours. Results of clinical field studies using Revolution monthly demonstrated ›90% control of flea infestations within 30 days of the first dose. Dogs and cats treated with Revolution, including those with pre-existing flea allergy dermatitis, showed improvement in clinical signs associated with fleas as a direct result of eliminating the fleas from the animals and their environment.

If the dog or cat is already infested with fleas when the first dose of Revolution is administered, adult fleas on the animal are killed and no viable fleas hatch from eggs after the first administration. However, an environmental infestation of fleas may persist for a short time after beginning treatment with Revolution because of the emergence of adult fleas from pupae.

Heartworm Prevention in Dogs and Cats

For the prevention of heartworm disease, Revolution must be administered on a monthly basis. Revolution may be administered year-round or at least within one month after the animal’s first exposure to mosquitoes and monthly thereafter until the end of the mosquito season. The final dose must be given within one month after the last exposure to mosquitoes. If a dose is missed and a monthly interval between dosing is exceeded then immediate administration of Revolution and resumption of monthly dosing will minimize the opportunity for the development of adult heartworms. When replacing another heartworm preventive product in a heartworm disease prevention program, the first dose of Revolution must be given within a month of the last dose of the former medication.

Selamectin, the active ingredient in Revolution, is a macrocyclic lactone compound. These compounds effectively prevent the development of adult heartworms when administered to dogs and cats within one month of exposure to infective (L3) Dirofilaria immitis larvae. Efficacy of macrocyclic lactones decreases below 100% in dogs, however, if first administered ›2 months after exposure to infective larvae. Thus, in heartworm endemic regions, delaying initiation of heartworm prevention using Revolution beyond 2 months of first exposure to infective larvae (e.g., starting puppies and kittens at ›8 weeks of age), or gaps of ›2 months in the administration of Revolution during periods of heartworm transmission, increases the risk of the animal acquiring heartworms. Animals with unknown heartworm history that test negative for heartworms prior to the initiation of Revolution may be harboring pre-patent infections at the time Revolution was started. Testing such animals 3-4 months after initiation of Revolution would be necessary to confirm their negative heartworm status.

At the discretion of the veterinarian, cats ≥6 months of age may be tested to determine the presence of existing heartworm infections before beginning treatment with Revolution. Cats already infected with adult heartworms can be given Revolution monthly to prevent further infections.

Ear Mite Treatment in Dogs and Cats

For the treatment of ear mite (O. cynotis) infestations in dogs and cats, Revolution should be administered once as a single topical dose. A second monthly dose may be required in some dogs. Monthly use of Revolution will control any subsequent ear mite infestations. In the clinical field trials ears were not cleaned, and many animals still had debris in their ears after the second dose. Cleansing of the infested ears is recommended to remove the debris.


User Safety Warnings

Not for human use. Keep out of the reach of children.

In humans, Revolution may be irritating to skin and eyes.

Reactions such as hives, itching and skin redness have been reported in humans. Individuals with known hypersensitivity to Revolution should use the product with caution or consult a health care professional. Revolution contains isopropyl alcohol and the preservative butylated hydroxytoluene (BHT).

Wash hands after use and wash off any product in contact with the skin immediately with soap and water.

If contact with eyes occurs, then flush eyes copiously with water; if wearing contact lenses, rinse the eyes first then remove contact lenses and continue to rinse for 5-10 minutes and seek medical attention.

In case of ingestion by a human, contact a physician immediately.


Prior to administration of Revolution, dogs should be tested for existing heartworm infections. At the discretion of the veterinarian, infected dogs should be treated to remove adult heartworms. Revolution is not effective against adult D. immitis and, while the number of circulating microfilariae may decrease following treatment, Revolution is not effective for microfilariae clearance.

Hypersensitivity reactions have not been observed in dogs with patent heartworm infections administered Revolution.


What is the most important information I should know about Revolution (Selamectin)?
Revolution (Selamectin) is a prescription medication applied topically once a month. Do not use Revolution® (Selamectin) on puppies under 6 weeks of age or kittens under 8 weeks of age. According to the product literature, Revolution® (Selamectin) is safe for use on pregnant or lactating dogs and cats.

What happens if I miss applying a dose of Revolution (Selamectin)?
Give the missed dose as soon as you remember. Do not give a double dose of the medication.

What happens if I overdose my pet on Revolution (Selamectin)?
Seek emergency veterinary medical treatment. Symptoms of overdose, while rare, may include salivation and lack of coordination, as well as symptoms listed below as side effects.

What should I avoid while using Revolution (Selamectin) on my pet?
Because humans can contract hookworms from animals, it is important to maintain good personal hygiene. It is also important to eliminate fleas on your pet and in the household and to not feed your pet rodents or uncooked meat or fish. To prevent reinfection, daily cleanup of stools is recommended. Do not use on sick, weak, or underweight animals. Do not apply to wet hair. Dogs should be tested for heartworms prior to using Revolution® (Selamectin). In humans, Revolution® (Selamectin) may be irritating to skin and eyes. Wash hands thoroughly after applying Revolution (Selamectin) to your pet.

What are the possible side effects of Revolution (Selamectin)?
Side effects of Revolution (Selamectin) that may occur include temporary hair loss at the site of application, loss of appetite, drooling, vomiting, diarrhea, drowsiness, rapid breathing, increased heart rate, and muscle tremors.

What other drugs will affect Revolution (Selamectin)?
Do not apply Revolution (Selamectin) to your pet if already giving an alternate heartworm medication. When switching from another heartworm medication, begin Revolution (Selamectin) when the next dose of the heartworm medication is due.

What should I discuss with my veterinarian before applying Revolution (Selamectin) on my pet?
Tell your veterinarian if your pet has ever had an allergic reaction to the medication.