Senergy Topical Solution for Extra Large Dogs, 85.1-130 lbs (Plum Box)

Monthly Selamectin Spot-On for Parasite Protection in Extra-Large Dogs

Product Description

Senergy Topical Solution (Plum Box) is an FDA-approved, prescription-only monthly spot-on for dogs and puppies 6 weeks or older weighing 85.1 to 130 lbs. Each carton contains 3 single-dose tubes, each with 3 mL (360 mg) of selamectin, the highest dose in the Senergy dog range. It prevents heartworm disease, kills adult fleas, prevents flea egg hatching, treats ear mites, controls American dog ticks, and treats sarcoptic mange.

Benefits

• Prevents Heartworm Disease: Selamectin prevents Dirofilaria immitis larval development into adult heartworms when applied within one month of exposure to infective larvae.
• Kills Fleas and Prevents Infestations: Kills adult Ctenocephalides felis fleas and prevents flea eggs from hatching for a full month after each application.
• Treats Ear Mites: Controls Otodectes cynotis ear mite infestations in extra-large dogs with each monthly topical application.
• Controls American Dog Ticks: Controls Dermacentor variabilis American dog tick infestations in extra-large dogs and puppies with monthly application.
• Treats Sarcoptic Mange: Treats and controls Sarcoptes scabiei infestations in extra-large dogs and puppies with each monthly dose.
• Highest Single-Tube Dog Dose: The Plum Box delivers 360 mg of selamectin, the highest single-tube dose in the entire Senergy dog range, for full therapeutic coverage.
• 3-Month Supply per Carton: Each Plum Box carton contains 3 single-dose tubes, providing a convenient 3-month supply for consistent year-round protection.

Ingredients

Composition Table

Other Ingredients

Isopropyl alcohol, Butylhydroxytoluene (BHT)

How to Use

Directions for Use

• Prescription Required: US federal law limits use of this medication to cases approved or directed by a licensed veterinarian.
• Minimum Dose: One tube supplies at least 2.7 mg selamectin per pound (6 mg/kg), so the entire contents are used monthly.
• Open the Tube Correctly: Hold the tube upright with the expiration date visible at the bottom, then bend the tip backward until it snaps off.
• Apply at Base of Neck: Divide the hair at the neck area in front of the shoulder blades and apply the entire dose directly to the skin.
• Apply Once Monthly: Administer every month for continuous heartworm prevention, flea control, and parasite protection throughout the year.
• For Dogs Over 130 lbs: Your veterinarian will guide you on which Senergy tubes to use together to meet the total dose needed.
• Wash Hands After Use: Wash hands thoroughly with soap and water after application as selamectin may be irritating to human skin and eyes.
• Test for Heartworm Before Starting: All dogs should be tested for existing heartworm disease before starting a heartworm prevention protocol with Senergy.
• Switching From Another Preventive: Give the first Senergy dose within one month of the last dose of the former heartworm preventive product.

Disclaimer: This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any supplement for your pet.

Additional Information

Precautions

• Minimum Age: Do not use in puppies younger than 6 weeks of age; safety below this age has not been established.
• Sick or Debilitated Dogs: Never apply Senergy to sick, underweight, or debilitated dogs regardless of their age or body weight.
• Not Effective Against Adult Heartworms: Selamectin does not kill adult Dirofilaria immitis; test and treat for existing adult infections before starting preventive therapy.
• Gaps in Treatment: Gaps of more than 2 months in administration during heartworm season significantly increase the risk of infection.
• Highly Flammable Product: Keep tubes away from heat, open flames, sparks, and all sources of ignition at all times.
• Eye Contact: If the solution contacts the eyes of the dog or handler, flush immediately with copious amounts of water.
• Human Skin Sensitization: Repeated skin contact may cause localized allergic reactions including redness, itching, and hives; wear gloves and wash hands after use.
• Dogs Only: The Plum Box is dosed for dogs only; do not use on cats or other species.

Possible Side Effects

• Hair Loss at Application Site: Temporary hair loss or clumping at the application site has been reported and is typically a self-resolving cosmetic effect.
• Digestive Upset: Vomiting and diarrhea have been reported; accidental oral ingestion may also cause salivation and intermittent vomiting.
• Skin Reactions at Application Site: Redness, irritation, or skin sensitivity at the application site have been reported in some dogs.
• Hypersensitivity Reactions: Rare anaphylactic reactions are possible; contact your veterinarian immediately if hives, facial swelling, or collapse occurs.

Storage Information

• Store Below 77°F: Store below 25°C (77°F) and avoid exposure to excessive heat and direct sunlight.
• Keep Away from Children and Pets: Store this prescription product securely out of reach of children and other animals at all times.

Shipping & Return

We offer ground, express, and priority delivery; see our shipping policy for details.

For return instructions or product concerns, please refer to our detailed refund policy.

Prescription items are NON-RETURNABLE and NON-REFUNDABLE.

Frequently Asked Questions

Q1: What does Senergy Topical (Plum Box) treat and prevent in extra-large dogs?

Ans: Senergy Plum Box is a once-monthly topical solution that prevents heartworm disease, kills adult fleas, prevents flea egg hatching for one month, controls American dog ticks, treats ear mites, and treats sarcoptic mange. Approved use is for dogs and puppies 6+ weeks old with a body weight of 85.1–130 lbs.

Q2: How does the Plum Box differ from the Teal Box?

Ans: The Plum Box contains 360 mg of selamectin in a 3 mL tube, the highest single-tube dose in the Senergy dog range, compared to 240 mg in the Teal Box's 2 mL tube. Both provide identical parasite coverage at the same minimum dose of 2.7 mg/lb. Always use the tube that best matches your dog's current body weight.

Q3: My extra-large dog weighs more than 130 lbs. Can I still use Senergy?

Ans: Yes. For dogs over 130 lbs, the appropriate combination of available Senergy tube sizes should be used to achieve the correct total dose of 2.7 mg/lb selamectin, as directed by your veterinarian. Never rely on a single Plum Box tube alone if your dog's weight exceeds 130 lbs.

Q4: Can Senergy Plum Box be used on breeding or pregnant extra-large dogs?

Ans: Yes. Selamectin has been tested safe in pregnant and lactating females across over 100 dog breeds with no adverse effects observed. Safe use in breeding males has also been evaluated with no adverse effects reported. Speak with your veterinarian before giving any parasite prevention products to breeding animals.

Q5: Can Senergy treat an active heartworm infection in extra-large dogs?

Ans: No. Selamectin does not kill adult Dirofilaria immitis and is not intended for clearing microfilariae. Dogs must be tested for heartworm prior to starting Senergy, and any infection should be fully treated before using it monthly.

Clinical Research

Selamectin (Active Ingredient): FDA substance profile detailing.

Heartworm Disease: Educational overview from the American Heartworm Society

Sarcoptic Mange: Veterinary guide by MSD