Simparica Trio for Dogs 2.8-5.5 lbs

Zoetis SKU: 10022667


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1 Chewable Tablet
3 Chewable Tablets
6 Chewable Tablets
12 Chewable Tablets

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Simparica Trio for Dogs 2.8-5.5 lbs

Help your furry friend fight off pests with Simparica Trio Chewable Tablets for Dogs! Every purchase comes with 6 treatments that are specially formulated for canine companions 8 weeks of age and older, in their specified weight ranges. Simparica Trio is the first and only product that combines sarolaner, moxidectin and pyrantel in each treatment to help prevent heartworm disease, kill fleas before they can lay eggs, kill 5 types of ticks, treat and prevent flea infestations and treat and control roundworms and hookworms. And each monthly chewable tablet has a palatable liver flavor and can be taken with or without food!


Monthly Simparica Trio prevents heartworm disease, kills adult fleas and is indicated for the treatment and prevention of flea infestations, the treatment and control of tick infestations, and the treatment and control of roundworm and adult hookworm infections in dogs and puppies 8 weeks of age and older, and weighing 2.8 pounds or greater.

Prescription items are NON-RETURNABLE and NON-REFUNDABLE.

Please note product may arrive in a Hardy Paw Pharmacy vial, manufacturer packaging is shown for reference.

Dosage and Administration:

SIMPARICA TRIO is given orally once a month, at the recommended minimum dose of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 µg/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt).

Dosage Schedule

Body Weight (lbs) Sarolaner per Tablet (mg) Moxidextin per tablet (mg) Pyrantel per Tablet (mg) Number of Tablets Administered
2.8 to 5.5 lbs 3 0.06 12.5 One
5.6 to 11.0 6 0.12 25 One
11.1 to 22.0 12 0.24 50 One
22.1 to 44.0 24 0.48 100 One
44.1 to 88.0 48 0.96 200 One
88.1 to 132.0 72 1.44 300 One
›132.0 Administer the appropriate combination of tablets.

SIMPARICA TRIO can be offered to the dog with or without food.

Care should be taken to ensure that the dog consumes the complete dose and that part of the dose is not lost or refused. If a dose is missed, give SIMPARICA TRIO immediately and resume monthly dosing.

Heartworm Prevention:

SIMPARICA TRIO should be administered at monthly intervals year.round or at least within one month of the animal’s first seasonal exposure to mosquitoes and continuing until at least 1 month after the dog’s last seasonal exposure. If a dose is missed, give SIMPARICA TRIO immediately and resume monthly dosing. When replacing a monthly heartworm preventive product, SIMPARICA TRIO should be given within one month of the last dose of the former medication.

Flea Treatment and Prevention:

Treatment with SIMPARICA TRIO may begin at any time of the year. SIMPARICA TRIO should be administered year-round at monthly intervals or started at least one month before fleas become active.

To minimize the likelihood of flea re-infestation, it is important to treat all dogs and cats within a household with a flea control product.

Tick Treatment and Control:

Treatment with SIMPARICA TRIO can begin at any time of the year. SIMPARICA TRIO should be administered year-round at monthly intervals or started at least one month before ticks become active.

Intestinal Nematode Treatment and Control:

For the treatment of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina) and hookworm (L4, immature adult, and adult Ancylostoma caninum and adult Uncinaria stenocephala) infections, SIMPARICA TRIO should be administered once as a single dose. Monthly use of SIMPARICA TRIO will control any subsequent infections.


There are no known contraindications for the use of SIMPARICA TRIO.


Not for use in humans. Keep this and all drugs out of reach of children.

Keep SIMPARICA TRIO in a secure location out of reach of dogs, cats and other animals to prevent accidental ingestion or overdose.


Sarolaner, one of the ingredients in SIMPARICA TRIO, is a member of the isoxazoline class. This class has been associated with neurologic adverse reactions including tremors, ataxia, and seizures. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures. Use with caution in dogs with a history of seizures or neurologic disorders.

Prior to administration of SIMPARICA TRIO, dogs should be tested for existing heartworm infections. Infected dogs should be treated with an adulticide to remove adult heartworms. SIMPARICA TRIO is not effective against adult D. immitis.

The safe use of SIMPARICA TRIO has not been evaluated in breeding, pregnant, or lactating dogs.


How is Simparica Trio different from other preventatives?
Simparica Trio is the first monthly chewable to protect dogs against heartworm disease, 5 types of ticks, fleas, roundworms and hookworms, all in only one monthly chewable.

Is Simparica Trio safe?
Simparica Trio has been demonstrated safe for dogs as young as 8 weeks old, and weighing as little as 2.8 lbs.

How often do you give Simparica Trio?
Give a Simparica Trio chewable to your dog once a month.

How do I switch from another heartworm medication or tick and flea medication?
Talk to your veterinarian about switching to Simparica Trio from another preventive medication to ensure your dog is kept protected through the process.

Do I need a prescription for Simparica Trio?
Yes. Your veterinarian can prescribe the correct dose for your dog. Talk to your vet today about Simparica Trio.

What if I’m late giving a Simparica Trio dose?
If a dose is missed, a new dose should be given immediately. If a dose is vomited or spit out, a new dose should be given again. Then, continue on the prescribed monthly dosing schedule.

How fast does Simparica Trio work to kill ticks and fleas?
Simparica Trio works to get rid of ticks and fleas on dogs fast. It starts to kill deer ticks within 8 hours, and fleas within 4 hours.

When can I start Simparica Trio for a puppy?
You can begin using Simparica Trio with puppies as young as 8 weeks old weighing at least 2.8 lbs.

Can Simparica Trio help to prevent Lyme infections?
Simparica Trio is FDA-approved to prevent infections that may cause Lyme disease by killing deer ticks.