SMZ/TMP (sulfamethoxazole and trimethoprim) 80mg/16mg Injection (30 ml)

Broad-Spectrum Antibiotic Injection for Dogs and Cats

Product Description

Sulfamethoxazole and Trimethoprim Injection is a duo-action antibiotic used to clear up severe bacterial issues in animals when they cannot take medicine by mouth. It is frequently prescribed for bladder infections, specific stomach problems, and serious conditions like Pneumocystis pneumonia. This formula provides a two-pronged approach to fighting bacteria and is given through an IV while being monitored by a veterinarian.

Benefits

• Broad-spectrum coverage: Effectively targets multiple bacteria including E. coli, Klebsiella, Proteus, and Shigella species in serious infections.
• Dual-action mechanism: Combines sulfamethoxazole and trimethoprim to inhibit bacterial folate synthesis at two sequential steps, enhancing antibacterial effectiveness.
• IV treatment option: Suitable for pets requiring intravenous therapy when oral administration is not feasible or practical.
• Severe infection support: Used in complicated urinary tract infections and systemic infections requiring aggressive antimicrobial treatment.
• Flexible dosing regimens: Allows dosing adjustments based on infection type, severity, and renal function for safe clinical use.

Ingredients

Composition Table

How to Use

Recommended-Dosage Chart

Dosage & Administration Instructions

• IV administration only: Give this medication through an intravenous drip over 60 to 90 minutes, making sure not to inject it too quickly or all at once.
• Proper dilution required: Mix each 5 mL with the correct amount of 5% dextrose solution before giving it, exactly as you were taught.
• No intramuscular use: Do not give this as a muscle injection for any reason because of safety concerns and how the medicine is made.
• Inspect before use: Check for particulate matter, discoloration, or crystallization and discard solution if abnormalities are observed.
• Renal dose adjustment: Adjust dosage in patients with impaired renal function based on creatinine clearance levels.
• Prescription required: This medication should only be used under veterinary supervision as a prescription-based antibiotic therapy.

Disclaimer: This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any supplement for your pet.

Additional Information

Precautions

• Hypersensitivity risk: Stop treatment immediately if a rash or allergic response appears, as these can quickly become severe or life-threatening.
• Pregnancy caution: This should only be used during pregnancy if the benefits are greater than the risks, as it could potentially harm or cause birth defects in the fetus.
• Electrolyte monitoring: Keep a close eye on potassium and sodium levels, since this medication can cause these levels to become dangerously high or low.
• Renal impairment caution: Use with extra care in patients with kidney issues; they will need regular check-ups and likely a change in their dose.
• Avoid drug interactions: Do not use this at the same time as certain other medicines like warfarin, methotrexate, or ACE inhibitors to avoid dangerous interactions.

Possible Side Effects

• Stomach issues: Feeling sick, throwing up, loose stools, and losing interest in food are common side effects during treatment.
• Skin reactions: Patients might experience rashes, hives, or severe conditions such as Stevens-Johnson syndrome while using this medication.
• Blood changes: This treatment can sometimes lead to issues like low platelet levels, anemia, or a decrease in white blood cells.
• Kidney complications: Reported effects include kidney failure, internal swelling of the kidneys, or crystals forming in the urine.
• Neurological symptoms: Headaches and dizziness can happen, and in rare instances, a patient might experience seizures or a specific type of meningitis.

Storage Information

• Use promptly after dilution: Use the mixed liquid within the set time frame and do not put it in the fridge once it is ready.
• Discard unstable solution: Throw away the mixture if it looks cloudy or shows crystals after stirring to make sure it is safe to give.
• Vial usage limit: Finish the medicine in multi-dose bottles within 48 hours of the first opening to keep the product working correctly.
• Proper handling required: Store and handle according to standard sterile injectable product guidelines to prevent contamination.

NOTE: For generic medications, the product image shown may not reflect the actual item received. Generic medications can vary in size, color, and shape between orders depending on the manufacturer. Additionally, your medication may arrive packaged in a HardyPaw Pharmacy vial.

Shipping & Return

We offer ground, express, and priority delivery; see our shipping policy for details.

For return instructions or product concerns, please refer to our detailed refund policy.

Prescription items are NON-RETURNABLE and NON-REFUNDABLE.

Frequently Asked Questions

Q1: What is SMZ/TMP Injection used for in pets?

Ans: SMZ/TMP Injection is prescribed for severe bacterial issues like bladder infections, shigellosis, and Pneumocystis pneumonia when pills cannot be used. It targets specific types of bacteria and is generally given through an IV while being monitored by a veterinarian.

Q2: How is sulfamethoxazole and trimethoprim injection administered?

Ans: Sulfamethoxazole and trimethoprim injection is administered via intravenous infusion over 60 to 90 minutes after proper dilution with 5% dextrose solution. It should not be given as a rapid injection or intramuscularly due to safety concerns.

Q3: Can Sulfamethoxazole and trimethoprim injection be used in pets with kidney issues?

Ans: Sulfamethoxazole and trimethoprim injection requires dosage adjustments in patients with impaired renal function. Reduced dosing is recommended for moderate impairment, while use is not advised in severe renal insufficiency without proper monitoring of kidney function.

Q4: What are the common side effects of trimethoprim-sulfamethoxazole injection?

Ans: Trimethoprim-sulfamethoxazole injection may cause side effects such as nausea, vomiting, skin rash, and allergic reactions. In some cases, serious reactions like blood disorders or severe skin conditions may occur, requiring immediate discontinuation and medical attention.

Q5: Are there any important precautions with SMZ-TMP IV injection?

Ans: SMZ-TMP IV injection should be used cautiously in patients with allergies, renal impairment, or electrolyte imbalances. Monitoring of blood counts, kidney function, and electrolytes is essential, and therapy should be discontinued if serious adverse reactions develop.

Clinical Research:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/018374s025lbl.pdf

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b89b5502-ce87-45a6-a43c-9891da3cfca4