Spironolactone / Hydrochlorothiazide Tablets, 25mg

Combination Diuretic Tablets for Heart Failure and Fluid Retention in Pets

Product Description

Spironolactone and Hydrochlorothiazide 25mg Tablets are a prescription combination diuretic used by veterinarians to treat congestive heart failure and fluid retention in dogs and cats. Spironolactone holds onto potassium while clearing excess fluid, while hydrochlorothiazide pushes sodium and fluid out through the kidneys. The two together are often the go-to when pets stop responding to other diuretics, and they also help manage abdominal fluid buildup from liver disease.

Benefits

• Congestive Heart Failure Treatment: Clears excess fluid and salt from the body to take the pressure off pets dealing with congestive heart failure.
• Potassium-Sparing Combination: Spironolactone keeps potassium levels stable when hydrochlorothiazide and other diuretics would otherwise deplete them during treatment.
• Ascites Management: Helps reduce abdominal fluid buildup caused by liver failure or other underlying conditions in dogs and cats.
• Blood Pressure Reduction: Works alongside other cardiac medications to bring blood pressure down and offer some protection to the heart muscle.
• Refractory Edema Support: A practical option for pets whose fluid retention has not improved on other diuretics used in standard treatment plans.

Ingredients

Active Ingredients

Spironolactone 25mg, Hydrochlorothiazide 25mg

How to Use

Spironolactone / Hydrochlorothiazide 25mg Tablets are a prescription-only medication. A valid veterinarian prescription is required to purchase this product.

Please follow your veterinarian's specific instructions for the dosage and administration of this medication for your pet.

Disclaimer: Dosage and administration of this medication must be determined by a licensed veterinarian. Always consult your veterinarian before administering or adjusting any prescription medication for your pet.

Tucking this tablet into a soft pill pocket or pill wrap treat is a simple way to get your pet to take their dose without any fuss. Pairing it with a small amount of food is also a good idea to help keep stomach discomfort at bay.

Shop Pill Pockets for Dogs | Shop Pill Pockets for Cats

Additional Information

Precautions

• Avoid in Kidney Failure: Pets with anuria, acute kidney insufficiency, or serious kidney impairment should not be started on this medication.
• Avoid in Hyperkalemia: Pets already running high on blood potassium should not receive this medication, as spironolactone may push those levels even higher.
• Avoid in Addison's Disease: Pets with Addison's disease should not be given this medication due to the serious electrolyte complications it can trigger.
• Caution in Liver Disease: Pets with liver disease need close monitoring on this medication, even though it is also used to treat ascites in liver failure.
• Wear Gloves When Handling: Spironolactone is listed as a hazardous drug by NIOSH, so gloves should be worn when handling, particularly during pregnancy.
• Drug Interaction Risk: Share a full list of your pet's current medications, including ACE inhibitors, NSAIDs, digoxin, insulin, and potassium supplements, with your veterinarian before starting.
• Regular Bloodwork Required: Keeping tabs on electrolyte levels and kidney function through routine blood tests is an important part of staying on top of your pet's health during treatment.

Possible Side Effects

• Electrolyte Imbalances: Shifts in potassium or sodium levels are among the more commonly seen reactions and tend to improve once the medication is stopped.
• Dehydration Signs: Unusual thirst, less urination, weakness, tiredness, dizziness, and muscle cramps can all point to dehydration that needs veterinary attention.
• Digestive Upset: Vomiting, diarrhea, and a drop in appetite can come up, more so at higher doses or when treatment is just getting started.
• Facial Dermatitis in Cats: Itchy skin sores on the face are a serious reaction seen mostly in Maine Coon cats and need immediate veterinary attention.
• Allergic Reactions: Labored breathing, a rash, fever, or swelling around the face may be signs of an allergic reaction that needs prompt veterinary care.

Storage Information

• Store at Room Temperature: Keep tablets at or below 77°F inside a childproof, light-resistant container away from heat and moisture.
• Protect From Light: A light-resistant container helps both active ingredients hold their potency and stay stable over time.
• Out of Reach: Keep this medication somewhere children and untreated animals in the home cannot get to it.

NOTE: For generic medications, the product image shown may not reflect the actual item received. Generic medications can vary in size, color, and shape between orders depending on the manufacturer. Additionally, your medication may arrive packaged in a HardyPaw Pharmacy vial.

Shipping & Return

We offer ground, express, and priority delivery; see our shipping policy for details.

For return instructions or product concerns, please refer to our detailed refund policy.

Prescription items are NON-RETURNABLE and NON-REFUNDABLE.

Frequently Asked Questions

Q1: What conditions do spironolactone and hydrochlorothiazide tablets treat in dogs and cats?

Ans: This combination is prescribed for congestive heart failure, fluid retention, high blood pressure, and ascites from liver disease in dogs and cats. It tends to be the next step when pets have not responded well enough to other diuretics as part of their cardiac care plan.

Q2: Why is spironolactone considered a potassium-sparing diuretic for pets?

Ans: Spironolactone targets aldosterone receptors in the kidneys, which lets the body hang onto potassium instead of flushing it out. This pairs well with hydrochlorothiazide, which tends to pull potassium out of the body and can lead to significant depletion without something to counterbalance it.

Q3: Are there any special handling precautions for spironolactone tablets?

Ans: Spironolactone is flagged as a hazardous drug by NIOSH, so wearing gloves when handling the tablets is important, especially for anyone who is pregnant. If skin contact happens accidentally, washing the area well with water is recommended. Keep the medication away from children and other animals at all times.

Q4: What are the signs of a serious reaction to this medication in cats?

Ans: Maine Coon cats in particular can develop itchy, sore skin lesions on the face, which is a serious and uncommon reaction to watch out for. Facial swelling, labored breathing, vomiting, or a sudden drop in drinking and urinating are also warning signs that need immediate veterinary attention.

Q5: What regular monitoring is needed while a pet is on this medication?

Ans: Routine blood tests to check potassium, sodium, and kidney function are an important part of keeping pets safe on this medication. Blood pressure should also be tracked regularly. When the dose is first started or changed, a veterinarian may want to run tests more often to stay on top of any shifts.