Tri-Heart Plus Chewable Tablet for Large Dogs 51-100 lbs

Monthly Heartworm & Intestinal Parasite Prevention for Large Dogs (51–100 lbs)

Product Description

Tri-Heart Plus Chewable Tablets (Brown Box) are a prescription, once-monthly oral treatment built specifically for large dogs weighing between 51 and 100 pounds. Each beef-flavored tablet combines Ivermectin and Pyrantel to prevent heartworm disease and clear roundworm and hookworm infections in one monthly dose. Widely regarded as the number one veterinarian-recommended generic heartworm preventive, it delivers the same protection as Heartgard Plus at a friendlier price point. Suitable for puppies from six weeks of age and older.

Benefits

• Heartworm Disease Prevention: Clears the tissue stage of heartworm larvae (Dirofilaria immitis) within 30 days of infection, stopping worms well before they can reach the heart.
• Treats Roundworms: Works against Toxocara canis and Toxascaris leonina roundworm species, keeping these common intestinal parasites under control in large dog breeds.
• Treats Hookworms: Covers three hookworm species including Ancylostoma caninum, Uncinaria stenocephala, and Ancylostoma braziliense for thorough intestinal parasite control.
• Large Breed Dosing: Calibrated specifically for dogs between 51 and 100 pounds, so every large breed gets a dose that matches their body weight accurately.
• Easy to Give: The beef-flavored chewable is something most dogs take without any fuss, making the monthly routine simple and stress-free for large dog owners.
• Puppy Friendly: Can be given to puppies as young as six weeks old with no upper age restriction, covering dogs at every stage of life.
• Gluten-Free Formula: Free from wheat and rice gluten, making this tablet a safe monthly option for dogs that are sensitive to these ingredients.
• Cost-Effective Alternative: Carries the same active molecules at identical strengths as Heartgard Plus, offering the same level of protection at a noticeably lower cost.
• Backed by a Guarantee: When given year-round as directed, this product is covered by the manufacturer's guarantee, including diagnostic fees and a free one-year supply if a heartworm positive result occurs.

Ingredients

Composition Table

How to Use

Dosage & Administration Instructions

• Prescription Required: This product is available by prescription only and must be sourced through or under the direct order of a licensed veterinarian.
• Monthly Oral Dose: Give your large dog one full chewable tablet on the same date every month to keep protection running consistently throughout the year.
• Encourage Chewing: Offer the tablet in a way that gets your dog to chew it rather than gulp it down whole, as chewing ensures the active ingredients are properly absorbed.
• Alternative Methods: The tablet can be handed over directly, added to a small portion of dry food, or broken into pieces for dogs that tend to swallow things whole.
• One Tablet at a Time: Pull just one tablet from the blister card right before giving it, as the sealed packaging is there to protect the tablet from air and light exposure.
• Dogs Over 100 lbs: Your veterinarian will advise on the right combination of tablet sizes to reach the correct total dose for dogs above this weight range.
• Seasonal Use: For seasonal dosing, the first tablet should go out within 30 days of the first mosquito exposure and the last within 30 days of the season ending.
• Missed Dose: Give the missed dose as soon as you remember and carry on with the monthly schedule; get in touch with your vet if the gap has stretched past 30 days.
• Set a Reminder: Sign up for free monthly email reminders from the manufacturer or use the reminder stickers inside each pack to stay on top of the dosing schedule.

Disclaimer: This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any medication for your pet.

Additional Information

Precautions

• Heartworm Screening First: Every dog should be checked for heartworm by a vet before the first tablet is given, as this product is not designed to clear established heartworm infections.
• Not for Heartworm-Positive Dogs: Dogs already carrying heartworms must go through treatment to remove adult worms and microfilariae before this product can be introduced.
• Dogs Only: This product is not approved for cats and must never be given to them under any circumstances.
• Herding Breed Caution: Certain herding breeds such as Collies and Australian Shepherds may carry the MDR1 mutation, which can cause reactions to ivermectin; always check with your vet first.
• No Double Preventives: This product must not be given at the same time as another heartworm preventive medication; only one should be in use at any given time.
• Breeding Females: Safety during pregnancy and while nursing has not been fully confirmed; always seek veterinary advice before treating females that are pregnant or lactating.
• Intact Blister Pack Only: If the foil seal on the blister pack appears peeled back, pierced, or damaged in any way, do not use the tablet inside.
• Keep Sealed Until Use: Leave each tablet inside its blister wrapper right up until the moment you are ready to hand it to your dog.

Possible Side Effects

• Digestive Upset: Vomiting, loose stools, reduced appetite, excessive drooling, and lip licking have been noted in a small number of dogs after taking this tablet.
• Neurological Reactions: In less common cases, dogs may show signs of depression, unsteady movement, dilated pupils, shaking, or convulsions following ivermectin administration.
• Overdose Risk: Giving more than the recommended dose can result in tremors, significant weight loss, dilated pupils, or in serious cases, life-threatening outcomes; contact your vet immediately if an overdose is suspected.

Storage Information

• Room Temperature Storage: A steady indoor spot that sits between 59°F and 86°F (15°C to 30°C) is the right place to store this product safely.
• Protect from Light: Keep tablets inside their original blister packaging and away from any direct light source right up until the moment of use.
• Safe Storage Practice: Store this prescription tablet well out of reach of children and other household animals to prevent any chance of accidental ingestion.

Shipping & Return

We offer ground, express, and priority delivery; see our shipping policy for details.

For return instructions or product concerns, please refer to our detailed refund policy.

Prescription items are NON-RETURNABLE and NON-REFUNDABLE.

Frequently Asked Questions

Q1: What does Tri-Heart Plus (Brown Box) treat in large dogs?

Ans: Tri-Heart Plus (Brown Box) prevents heartworm disease and treats roundworms including Toxocara canis and Toxascaris leonina, and hookworms including Ancylostoma caninum, Uncinaria stenocephala, and Ancylostoma braziliense. It does not cover whipworms or tapeworms in large dogs.

Q2: How does the Brown Box formula differ from the Green Box for medium dogs?

Ans: The Brown Box holds 272 mcg Ivermectin and 227 mg Pyrantel per tablet, while the Green Box carries 136 mcg Ivermectin and 114 mg Pyrantel. Both target the same parasites. The higher dose in the Brown Box ensures large breeds get full body-weight-appropriate coverage every month.

Q3: My large dog weighs over 100 lbs. Can I still use Tri-Heart Plus?

Ans: Yes. Dogs above 100 pounds can still be covered using the right combination of available tablet sizes, as directed by your veterinarian. Never assume a single tablet meant for a lower weight range will be enough to protect a dog above that threshold.

Q4: Can Tri-Heart Plus be given to a large dog that already has heartworms?

Ans: No. This product is not designed to clear established heartworm infections. Large dogs confirmed as heartworm positive must complete treatment to remove adult worms and microfilariae first, under full veterinary supervision, before this tablet can be used as a monthly preventive.

Q5: What should I do if I miss a monthly dose of Tri-Heart Plus for my large dog?

Ans: Give the missed dose as soon as you notice and continue the regular monthly schedule from there. Never double up on doses. If the gap has gone beyond 30 days, contact your vet, as a heartworm retest may be recommended before carrying on with the program.