Product title
Vendor
$19.99 | $24.99
Product title
Vendor
$19.99 | $24.99
Product title
Vendor
$19.99 | $24.99
Product title
Vendor
$19.99 | $24.99
5-in-1 Monthly Flea, Heartworm & Intestinal Parasite Protection for Large Dogs (60.1–120 lbs)
Product Description
Trifexis Chewable Tablets (Brown Box) are a prescription, once-monthly oral treatment for dogs and puppies weighing between 60.1 and 120 pounds. Each beef-flavored tablet brings together Spinosad and Milbemycin Oxime to tackle five different parasites in a single monthly dose. It kills fleas fast, keeps heartworm disease at bay, and clears adult hookworm, roundworm, and whipworm infections all at once. Works for puppies that are 8 weeks or beyond in age and have reached at least 5 pounds in weight.
Benefits
- Kills Fleas Fast: Spinosad starts killing fleas within 30 minutes of the tablet being given, reaching full flea kill effectiveness within 4 hours.
- Prevents Heartworm Disease: Milbemycin Oxime targets the L3 and L4 larval stages of Dirofilaria immitis before they grow into adult heartworms in large dogs.
- Controls Flea Infestations: Wipes out existing flea infestations and stops new ones; field studies recorded flea reductions of 98% to 99.8% over three monthly treatments.
- Treats Roundworms: Clears adult Toxocara canis and Toxascaris leonina infections with 90% or greater effectiveness against these common intestinal parasites.
- Treats Hookworms: Gets rid of adult Ancylostoma caninum infections, a parasite that can cause serious blood loss even in larger, stronger dogs.
- Treats Whipworms: Also tackles adult Trichuris vulpis infections, a level of coverage that many heartworm-only products simply do not offer.
- Large Breed Dosing: Formulated specifically for dogs between 60.1 and 120 pounds, making sure every large breed gets the right body-weight-based dose.
- Easy to Give: The beef-flavored tablet can be offered by hand, tucked into food, or given as a treat, making monthly dosing simple for large dog owners.
- No Drying Time Needed: Unlike topical treatments, there is no waiting period after giving this tablet; dogs can be handled and played with straight away.
- Widely Trusted Formula: Over 272 million doses across nearly ten years show how consistently this tablet has performed for dogs and their owners.
Ingredients
Active Ingredients (per tablet, 60.1–120 lb dogs)
Spinosad 1620 mg, Milbemycin Oxime 27 mg
Other Ingredients
The beef flavoring in this tablet comes from artificial beef flavoring derived from pork-based proteins and hydrolyzed soy, not from actual beef.
How to Use
Dosage & Administration Instructions
- Prescription Required: This FDA-approved medication can only be obtained through a licensed veterinarian with a valid veterinarian-client-pet relationship in place.
- Monthly Oral Dose: Give one full chewable tablet by mouth once every month, keeping to roughly the same date each time for consistent year-round coverage.
- Always Give With Food: This tablet must be given alongside a meal for best absorption; giving it on an empty stomach can reduce how well it works.
- How to Offer the Tablet: The tablet can be handed over directly, stirred into food, or hidden inside a treat; it is made to be palatable for large dogs.
- Watch After Dosing: Keep an eye on your dog for one hour after giving the tablet; if vomiting happens within that window, give a full replacement dose right away.
- Minimum Dose: Each tablet delivers at least 13.5 mg/lb (30 mg/kg) Spinosad and 0.2 mg/lb (0.5 mg/kg) Milbemycin Oxime per dose.
- Dogs Over 120 lbs: Your veterinarian will advise on the right combination of tablet sizes to reach the correct total dose for heavier dogs.
- Seasonal Use: When used during mosquito season only, begin dosing within one month of first mosquito exposure and continue for at least three months after the last.
- Missed Dose: If more than 30 days pass between doses, give the tablet with food right away and carry on with the regular monthly schedule from that point.
- Minimum Age and Weight: Safe for puppies that are at least 8 weeks old and have reached a body weight of 5 pounds.
Disclaimer: This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any medication for your pet.
Additional Information
Precautions
- Heartworm Screening First: Every dog should be checked for heartworm by a vet before the first dose, as adult heartworm infections already in the body are beyond what this product can treat.
- Not for Adult Heartworms: This product does not clear adult Dirofilaria immitis; dogs confirmed positive should go through adulticide therapy before starting this product.
- Three Doses for Full Cover: Fewer than three back-to-back monthly doses after the final mosquito exposure may leave gaps in heartworm prevention for your large dog.
- Avoid Use With Ivermectin: Serious reactions have been reported when Spinosad is combined with ivermectin; always tell your vet about every medication your dog is currently on.
- Dogs Only: This product was developed solely for dogs and must not be given to cats under any circumstances.
- High Microfilariae Counts: Dogs with a large number of circulating microfilariae may show brief, mild reactions such as laboured breathing, vomiting, or lethargy when given milbemycin oxime.
- Breeding Dogs: Check with your vet before giving this product to breeding females; safety in males intended for breeding has not been assessed.
- Fleas After Dosing: Any fleas seen within a month of dosing are newly hatched from existing pupae in the surroundings; they will be killed before they can breed.
- Worms in Stool: Intestinal worms passed in your dog's stool after dosing are a normal sign that the product is doing its job correctly.
Possible Side Effects
- Vomiting: Monitor your dog closely for 60 minutes post-dose and give a complete second tablet right away if the first one comes back up.
- Digestive Upset: Loose stools, a reduced appetite, or excessive drooling have been reported in some dogs following administration of this tablet.
- Low Energy: A noticeable drop in activity levels and longer-than-usual sleep periods have been reported in some treated large dogs.
- Skin Reactions: Itching, skin reddening, and localised skin inflammation have been observed in a number of dogs after receiving this product.
- Neurological Reactions: Trembling, shaking, poor coordination, and seizures have been reported post-approval; contact your vet right away if any of these appear.
- Severe Allergic Reaction: Though rare, facial swelling, hives, very pale gums, sudden collapse, or cold limbs all require urgent emergency veterinary care.
Storage Information
- Room Temperature Storage: Store it in a spot that stays between 68°F (20°C) and 77°F (25°C) and keep this product there consistently.
- Safe Storage Practice: Store this prescription product well out of reach of children and other household animals to prevent any accidental ingestion.
Shipping & Return
We offer ground, express, and priority delivery; see our shipping policy for details.
For return instructions or product concerns, please refer to our detailed refund policy.
Prescription items are NON-RETURNABLE and NON-REFUNDABLE.
Frequently Asked Questions
Q1: What parasites does Trifexis (Brown Box) protect large dogs against?
Ans: Trifexis provides 5-in-1 coverage in one monthly tablet: it kills fleas, prevents heartworm disease, and treats adult hookworms, roundworms, and whipworms. It covers the most common parasites large dogs face but does not include protection against ticks.
Q2: How does the Brown Box formula differ from smaller Trifexis variants?
Ans: The Brown Box holds 1620 mg Spinosad and 27 mg Milbemycin Oxime per tablet, the highest dose across the full Trifexis range. The Blue Box for 40.1 to 60 lb dogs carries half that amount. All variants deliver the same five-way protection; the larger dose ensures full coverage for heavy breeds.
Q3: My large dog weighs more than 120 lbs. Can I still use Trifexis?
Ans: Yes, dogs over 120 pounds can still be treated using the right mix of available Trifexis tablet sizes to hit the correct total dose. Your vet will work out the exact combination needed. Never rely on a single Brown Box tablet alone for a dog above that weight threshold.
Q4: Can Trifexis be given to a large dog that already has heartworms?
Ans: No. This product does not treat adult heartworms and is not cleared for that purpose. Every dog must be tested before starting. If a large dog tests positive, adulticide treatment should be completed first before this product is introduced as a preventive measure.
Q5: Does Trifexis contain anything that could affect dogs with food sensitivities?
Ans: The beef flavoring in this tablet comes from artificial beef flavoring using pork-based proteins and hydrolyzed soy, not real beef. Dogs with known soy or pork sensitivities should be checked with a vet before starting. The product does not contain gluten.