Product title
Vendor
$19.99 | $24.99
Product title
Vendor
$19.99 | $24.99
Product title
Vendor
$19.99 | $24.99
Product title
Vendor
$19.99 | $24.99
5-in-1 Monthly Flea, Heartworm & Intestinal Parasite Protection for Small-to-Medium Dogs (10.1–20 lbs)
Product Description
Trifexis Chewable Tablets (Orange Box) are a prescription, once-monthly oral treatment for dogs and puppies weighing between 10.1 and 20 pounds. Each beef-flavored tablet combines Spinosad and Milbemycin Oxime to take on five different parasites in a single monthly dose. It kills fleas quickly, blocks heartworm disease, and clears adult hookworm, roundworm, and whipworm infections all at once. Any puppy past the 8-week mark and weighing no less than 5 pounds is ready to start on this product.
Benefits
- Kills Fleas Fast: Spinosad gets to work on fleas within 30 minutes of the tablet being given and reaches complete flea kill effectiveness by the 4-hour mark.
- Prevents Heartworm Disease: Milbemycin Oxime targets the L3 and L4 larval stages of Dirofilaria immitis before they get the chance to develop into adult heartworms.
- Controls Flea Infestations: Clears out existing flea infestations and stops fresh ones from taking hold; field studies showed flea reductions of 98% to 99.8% over three treatments.
- Treats Roundworms: Delivers 90% or greater effectiveness against adult Toxocara canis and Toxascaris leonina roundworm infections in small-to-medium dogs.
- Treats Hookworms: Clears adult Ancylostoma caninum infections, a parasite known to cause serious blood loss even in otherwise healthy smaller dogs.
- Treats Whipworms: Takes care of adult Trichuris vulpis infections, a level of coverage that a good number of heartworm-only products do not offer.
- Easy to Administer: The beef-flavored tablet can be offered by hand, stirred into a meal, or hidden in a treat, making monthly dosing hassle-free for small-to-medium dog owners.
- No Drying Time Needed: There is no waiting period after giving this tablet; dogs can be cuddled and played with straight after their monthly dose.
- Trusted by Dog Owners: Close to ten years in use and upward of 272 million doses confirm just how reliable this parasite tablet has proven to be.
Ingredients
Active Ingredients (per tablet, 10.1–20 lb dogs)
Spinosad 270 mg, Milbemycin Oxime 4.5 mg
Other Ingredients
The beef flavoring in this tablet comes from artificial beef flavoring derived from pork-based proteins and hydrolyzed soy, not from real beef.
How to Use
Dosage & Administration Instructions
- Prescription Required: This FDA-approved tablet can only be sourced through a licensed veterinarian with a valid veterinarian-client-pet relationship in place.
- Monthly Oral Dose: Give one full chewable tablet by mouth once every month, keeping to roughly the same date each time for uninterrupted year-round coverage.
- Always Give With Food: This tablet must always be given alongside a meal; administering on an empty stomach may reduce how effectively it works.
- How to Offer the Tablet: Hand it over directly, mix it into food, or tuck it inside a treat; it is made to appeal to dogs in this weight range.
- Watch After Dosing: Stay with your dog for one hour after the tablet is given; follow up with a fresh full dose straight away if the stomach does not hold it down.
- Minimum Dose: Every tablet in this size delivers at least 13.5 mg/lb (30 mg/kg) Spinosad and 0.2 mg/lb (0.5 mg/kg) Milbemycin Oxime per monthly dose.
- Seasonal Use: For seasonal use, begin dosing within one month of first mosquito exposure and keep going for at least three months after the last mosquito season ends.
- Missed Dose: If the gap between doses stretches past 30 days, give the tablet with a meal right away and pick up the regular monthly schedule from that point.
- Minimum Age and Weight: Dogs that have passed 8 weeks of age and tipped the scale at 5 pounds or above can be given this tablet safely.
Disclaimer: This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any medication for your pet.
Additional Information
Precautions
- Heartworm Screening First: Every dog should have a heartworm check with their vet before the first dose, since adult heartworm infections already present are not something this product addresses.
- Not for Adult Heartworms: This product has no action against adult Dirofilaria immitis; dogs that test positive should finish adulticide treatment before starting on this tablet.
- Three Doses for Full Cover: Completing fewer than three back-to-back monthly doses after the last mosquito exposure may leave gaps in heartworm protection for your dog.
- Avoid Use With Ivermectin: Serious reactions have been noted when Spinosad and ivermectin are given together; always let your vet know about every medication your dog is currently receiving.
- Dogs Only: This product was made solely for dogs and must never be given to cats under any circumstances whatsoever.
- High Microfilariae Counts: Dogs with elevated circulating microfilariae may show brief, mild reactions such as laboured breathing, drooling, or low energy when milbemycin oxime is given.
- Breeding Dogs: Check with your vet before giving this product to females intended for breeding; safety in breeding males has not been formally assessed.
- Fleas After Dosing: Any fleas spotted within a month of dosing have hatched from pre-existing pupae in the environment and will be killed before getting the chance to reproduce.
- Worms in Stool: Finding intestinal worms in your dog's stool after dosing is completely normal and a clear sign that the product is working as it should.
Possible Side Effects
- Vomiting: The most frequently reported reaction, and more likely in puppies under 14 weeks; give a full replacement tablet right away if it occurs within the first hour.
- Digestive Upset: Loose stools, a drop in appetite, or heavier-than-normal drooling have been noted in some dogs following administration of this tablet.
- Low Energy: A noticeable dip in activity and longer sleep periods than usual have been reported in some dogs after receiving their monthly dose.
- Skin Reactions: Itching, skin reddening, and areas of localised skin inflammation have been seen in a number of dogs after taking this product.
- Neurological Reactions: Trembling, shaking, unsteady movement, and seizures have been noted post-approval; get your vet on the phone straight away if any of these appear.
- Severe Allergic Reaction: Though uncommon, facial swelling, hives, very pale gums, cold limbs, or sudden collapse all need urgent emergency veterinary care without delay.
Storage Information
- Room Temperature Storage: A steady indoor spot that holds between 68°F and 77°F (20°C to 25°C) is the right place to keep this product safe and effective.
- Safe Storage Practice: Store this prescription tablet well out of reach of children and other household animals to prevent any chance of accidental ingestion.
Shipping & Return
We offer ground, express, and priority delivery; see our shipping policy for details.
For return instructions or product concerns, please refer to our detailed refund policy.
Prescription items are NON-RETURNABLE and NON-REFUNDABLE.
Frequently Asked Questions
Q1: What parasites does Trifexis (Orange Box) protect small-to-medium dogs against?
Ans: Trifexis (Orange Box) covers five parasites in one monthly tablet: it kills fleas, prevents heartworm disease, and treats adult hookworms, roundworms, and whipworms. It handles the most common parasites dogs in this weight range face but does not cover ticks.
Q2: How does the Orange Box (10.1–20 lbs) differ from the Magenta Box (5–10 lbs)?
Ans: The Orange Box contains 270 mg Spinosad and 4.5 mg Milbemycin Oxime per tablet, while the Magenta Box carries 140 mg Spinosad and 2.3 mg Milbemycin Oxime. Both deliver the same five-way protection. Always pick the tablet size that matches your dog's current body weight.
Q3: My dog vomited shortly after taking Trifexis. What should I do?
Ans: Give a complete replacement tablet with food straight away if your dog brings the dose back up within the first hour. To lower the chance of it happening again, always pair the tablet with a full meal. Reach out to your vet if vomiting carries on or seems severe.
Q4: Can Trifexis be given to a dog in this weight range that already has heartworms?
Ans: No. This product does not treat adult heartworms and is not approved for that use. Every dog must be screened before starting. If a dog tests positive, adulticide treatment should be completed first before this tablet is introduced as a monthly preventive.
Q5: Does Trifexis contain anything that could affect dogs with food sensitivities?
Ans: The beef flavoring comes from artificial beef flavoring using pork-based proteins and hydrolyzed soy, not from real beef. Dogs with known soy or pork sensitivities should be assessed by a vet before starting. This product does not contain gluten.