Vetoryl Capsules (Trilostane) for Dogs - 10mg

Once-Daily Trilostane Capsule for Cushing's Disease in Dogs

Product Description

Vetoryl Capsules (Trilostane) 10 mg is an FDA-approved, prescription-only oral treatment for Cushing's disease in dogs. Each capsule holds 10 mg of trilostane, a synthetic steroid analogue that reduces cortisol production in the adrenal cortex. One capsule daily with food handles both pituitary-dependent and adrenal-dependent forms of the condition, making it a good fit for small dogs or those needing a step up from the 5 mg starting strength.

Benefits

• Treats Cushing's Disease: Suitable for both pituitary-dependent and adrenal-dependent hyperadrenocorticism, the two forms of Cushing's disease most commonly diagnosed in dogs.
• Targets the Root Cause: Trilostane works by reversibly inhibiting 3-beta-hydroxysteroid dehydrogenase in the adrenal cortex, stopping excess cortisol from being produced at the source.
• Clinically Proven Results: In clinical field studies, most dogs showed reduced thirst, less urination, and lower panting within 14 days of beginning treatment.
• Once-Daily Convenience: A single oral dose each day is all it takes, slotting neatly into a daily routine for ongoing disease management.
• Precise Dosing for Small Dogs: The 10 mg capsule gives veterinarians an accurate dosing step up for small dogs where the 5 mg strength falls short of what is therapeutically needed.
• Reversible Suppression: Because trilostane's effect on cortisol production is reversible, your veterinarian can fine-tune or stop treatment safely as your dog's condition changes.

Ingredients

Composition Table

Other Ingredients

Gelatin capsule shell, Lactose, Magnesium Stearate, Colloidal Silicon Dioxide

How to Use

Dosage & Administration Instructions

• Prescription Required: US Federal law limits this medication to use by or on the order of a licensed veterinarian only.
• For Dogs Only: This medication is for oral use in dogs only and must never be given to humans or other animal species.
• Starting Dose: Your veterinarian determines the right starting dose for your dog based on body weight and overall health before writing the prescription.
• Give With Food: A single morning dose with food supports better absorption and helps keep stomach upset to a minimum.
• Keep the Capsule Whole: Do not open, empty, or split the capsule; give it exactly as dispensed every time.
• Early Check-In: Your vet will want to reassess your dog around the 10 to 14 day mark with an ACTH stimulation test and a full biochemistry panel.
• Dose Adjustments: If test results or clinical signs call for a change, your veterinarian will guide any dose adjustment; never change the dose on your own.
• Watch for Warning Signs: Vomiting, diarrhea, tiredness, poor appetite, weakness, or collapse are all reasons to stop the medication immediately and contact your vet.
• Wash Hands After Handling: Always wash your hands with soap and water after touching the capsules.

Disclaimer: This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any supplement for your pet.

Additional Information

Precautions

• Hypersensitivity: Avoid use in any dog that has had an allergic reaction to trilostane in the past.
• Liver or Kidney Disease: Dogs with existing liver or kidney problems should not use this medication; organ function should be confirmed before starting.
• Not for Pregnant Dogs: Animal studies have linked trilostane to birth defects and early pregnancy loss; never give to a pregnant dog under any circumstances.
• Pregnant Handlers: Women who are pregnant or planning to conceive should not handle these capsules given the known risks trilostane poses to fetal development.
• Adrenal Over-Suppression: Addison's disease can develop at any dose level; recovery can take months and some dogs do not fully regain normal adrenal function.
• Heart Medications: Extra care is needed when a dog is already on heart treatment; share a full medication list with your vet before starting Vetoryl.
• Previous Mitotane Use: A minimum of one month must pass after stopping mitotane, and ACTH levels must normalize, before Vetoryl can safely begin.
• Lactating and Breeding Males: This medication has not been assessed for safety in nursing females or males used for breeding; seek veterinary advice before use.

Possible Side Effects

• Anorexia and Vomiting: Poor appetite and vomiting are the most frequently reported reactions; stop the medication and contact your vet if they occur.
• Lethargy and Weakness: Reduced energy, lower activity levels, and physical weakness have been noted regularly in clinical and post-approval reports.
• Diarrhea: Some dogs develop loose stools; track bowel changes and let your veterinarian know if anything seems off.
• Elevated Liver Enzymes: Liver enzyme increases have been observed in some dogs; routine bloodwork is the most reliable way to spot this early.
• Electrolyte Imbalances: Abnormal potassium or sodium levels can point to adrenal over-suppression and should be addressed with your vet promptly.
• Serious Adverse Events: Severe reactions including kidney failure and Addison's disease have in some cases resulted in death; seek urgent veterinary care if your dog suddenly collapses or deteriorates.

Storage Information

• Room Temperature Storage: Keep at around 25°C (77°F), away from moisture and direct sunlight.
• Keep Away from Children and Pets: Store this prescription medication somewhere children and other animals simply cannot get to.

Shipping & Return

We offer ground, express, and priority delivery; see our shipping policy for details.

For return instructions or product concerns, please refer to our detailed refund policy.

Prescription items are NON-RETURNABLE and NON-REFUNDABLE.

Frequently Asked Questions

Q1: What condition does Vetoryl (Trilostane) 10 mg treat in dogs?

Ans: Vetoryl 10 mg treats hyperadrenocorticism, commonly called Cushing's disease, in dogs. It covers both the pituitary-dependent form, which accounts for most cases, and the adrenal-dependent form, where a growth on the adrenal gland triggers excess cortisol production throughout the body.

Q2: How does the 10 mg capsule differ from the 5 mg capsule?

Ans: Both capsules contain trilostane and work the same way. The 10 mg capsule delivers double the dose in a single administration, making it the better choice for small dogs where the 5 mg strength does not quite reach a therapeutic level. Your vet will decide which strength is right based on your dog's weight.

Q3: How quickly does Vetoryl 10 mg start working in dogs?

Ans: Clinical studies found that most dogs showed visible improvement within 14 days of beginning Vetoryl. Reduced thirst, less frequent urination, and lower panting were among the first signs of progress. A follow-up ACTH stimulation test is typically scheduled at the 10 to 14 day point to assess how well the dose is working.

Q4: Why does my dog need regular testing while on Vetoryl 10 mg?

Ans: Even at a low dose, Vetoryl can tip adrenal suppression too far and lead to Addison's disease. Routine ACTH stimulation tests and biochemistry panels help keep cortisol in a safe range and give your vet what they need to make informed dose adjustments along the way.

Q5: Is Vetoryl (Trilostane) 10 mg a cure for Cushing's disease in dogs?

Ans: No. Vetoryl keeps the condition under control by reducing cortisol production, but the underlying disease does not go away. Once the medication stops, cortisol levels rise again and symptoms come back, which is why treatment is usually continued for the rest of the dog's life.

Clinical Research

FDA - Vetoryl Drug Approval

Merck Veterinary Manual – Cushing's Syndrome in Dogs

PetMD – Trilostane for Dogs