Zenrelia (ilunocitinib tablets) for Dogs, 15-mg

Targeted relief for itchy allergic dogs

Product Description

Zenrelia is an oral immunomodulator that helps manage itching and skin irritation caused by allergic and atopic dermatitis in dogs. It works by blocking specific JAK pathways that drive itch and inflammation, offering fast targeted relief while supporting long-term comfort. This treatment is suitable for dogs 12 months and older and is given once daily.

Benefits

·         Fast itch relief: Helps reduce itching caused by allergic and atopic dermatitis, improving comfort within the first days of use.

·         Targeted JAK inhibition: Blocks pruritogenic and inflammatory cytokines that contribute to itching and skin irritation in dogs.

·         Once daily dosing: Provides a simple treatment schedule that can be given with or without food for easier daily use.

·         Helps manage chronic dermatitis: Shown to reduce itch scores and improve skin lesion severity in controlled veterinary studies.

·         Suitable for long-term control: Evaluated in extended safety and effectiveness studies for continued management of allergic conditions.

Variants

·         4.8 mg

·         6.4 mg

·         8.5 mg

·         15 mg

Ingredients

Active Ingredients

Ilunocitinib

How to Use

Recommended Dosage Chart

Disclaimer: This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any supplement for your pet.

Dosage and Administration Instructions

·         Daily dosing: Give once daily at 0.27 to 0.36 mg per pound body weight according to your dog's prescribed tablet strength.

·         Food flexibility: May be administered with or without food, offering easy daily use regardless of your pet’s feeding routine.

·         Vaccination timing: Stop Zenrelia at least 28 days before any vaccine and resume only 28 days after vaccination.

·         Age requirement: Use only in dogs 12 months of age or older to ensure safe and appropriate treatment response.

·         Monitor health: Monitor for signs of infection since Zenrelia can increase susceptibility to certain bacterial or viral illnesses.

Additional Information

Precautions

·         Not for breeding dogs: Safety has not been evaluated in pregnant, breeding, or lactating dogs, so use is not recommended.

·         Avoid combination therapies: Not evaluated with steroids, cyclosporine, or other systemic immunosuppressants, and should not be combined.

·         Immune effects: Modulates the immune system and may affect normal immune responses, requiring veterinary guidance before use.

·         Prostate changes: Decreased prostate gland size was observed in intact male dogs during laboratory studies.

Possible Side Effects

·         Digestive issues: Vomiting, diarrhea, appetite loss, or stomach upset may occur during treatment according to clinical study findings.

·         Lethargy signs: Some dogs may experience decreased energy or fatigue during the early phases of therapy.

·         Respiratory symptoms: Coughing, wheezing, and occasional respiratory infections were reported in treated dogs during studies.

·         Skin growths: Dermal growths such as cysts or papillomas occurred in a percentage of treated dogs across clinical trials.

·         Urinary concerns: Urinary tract infections were noted among dogs receiving Zenrelia and may require veterinary monitoring.

·         Storage Information

·         Room temperature: Store at 59 to 77 degrees Fahrenheit with permitted short-term excursions between 41 and 104 degrees Fahrenheit.

·         Keep secure: Store in a locked or inaccessible area to prevent accidental ingestion by pets or children.

·         Original packaging: Keep tablets in their original blister or bottle packaging to maintain product stability and ensure correct dosing.

Shipping & Return

We offer ground, express, priority, and international delivery; see our shipping policy for details.

For return instructions or product concerns, please refer to our detailed refund policy.

Prescription items are NON-RETURNABLE and NON-REFUNDABLE.

Frequently Asked Questions

Q1: How does Zenrelia help reduce itching in dogs?

Ans: Zenrelia works by blocking specific JAK(Janus kinase) dependent cytokines that trigger itching and inflammation in allergic and atopic dermatitis. This targeted action helps reduce itch intensity and improve skin comfort in affected dogs when used as prescribed by a veterinarian.

Q2: How fast does Zenrelia start relieving my dog’s itching?

Ans: Clinical studies show that dogs receiving Zenrelia experience noticeable reductions in itching within the first several days of treatment. Improvement continues with daily use, and most dogs demonstrate meaningful itch reduction by Day 7 of therapy.

Q3: Can Zenrelia be given with food or on an empty stomach?

Ans: Zenrelia can be administered with or without food, allowing flexibility according to your dog’s routine. Although absorption increases with food, the manufacturer states that either method is acceptable for daily dosing when following prescribed instructions.

Q4: Can my dog receive vaccines while taking Zenrelia?

Ans: Dogs should not receive vaccines while taking Zenrelia because it may reduce vaccine effectiveness. The manufacturer advises stopping Zenrelia 28 days to 3 months before any vaccination and withholding it for at least 28 days after vaccination.

Q5: Is Zenrelia safe for all dogs?

Ans: Zenrelia is only approved for dogs 12 months of age or older. It should not be used in dogs with serious infections or those that are pregnant, breeding, or lactating. Veterinary supervision is required to ensure safe and appropriate use.