Bravecto vs NexGard: Which Flea and Tick Treatment Is Best for Dogs?

Bravecto vs NexGard: Which Flea and Tick Treatment Is Best for Dogs?

Edward Simmons

Which flea and tick treatment offers the best value, safety, and protection for your dog in 2025—Bravecto or NexGard? It’s a top concern for dog owners navigating a complex world of parasite preventatives like Bravecto, NexGard, Simparica Trio, and Trifexis where ingredients, safety profiles, side effects, and breed compatibility all matter.

In this comparison of Bravecto vs NexGard, you’re not just comparing labels - you’re making a decision that affects your pet’s comfort, disease risk, and day-to-day health management. 

📌 TL;DR: Bravecto vs NexGard 2025 

  • Bravecto lasts 12 weeks; NexGard is monthly.
  • Bravecto offers chew, topical, and injectable forms.
  • NexGard kills fleas faster; Bravecto kills ticks faster.
  • Bravecto is safer for pregnant and MDR1-sensitive dogs.
  • NexGard is better for monthly dosing and picky eaters.
  • Both need a vet prescription and work with heartworm meds.

The global flea and tick medication market is projected to grow at a CAGR of 7.4% from 2024 to 2030 [source]

Pet parents are increasingly seeking treatments that offer long-term efficacy, minimal side effects, and convenience—all while remaining affordable and safe.

From regional tick exposure to vet-recommended prevention schedules, the "best" option can shift based on your dog’s age, medical history, and ability to stick to a routine.

At HardyPaw, we remove the guesswork by offering vet-approved flea and tick preventatives all curated to help you match your dog’s needs with the most effective treatment available today.

This in-depth guide to Bravecto vs NexGard will help you:

  • Understand how Bravecto and NexGard function
  • Evaluate which offers better tick and flea protection
  • Assess safety, cost, and convenience
  • Get answers to real questions pet owners are asking right now

Understanding Bravecto and NexGard: What They Do for Your Dog

Before diving into comparisons, let’s quickly break down what Bravecto and NexGard are, how they work, and what makes them trusted names in flea and tick prevention.

What Is Bravecto?

Bravecto is a powerful flea and tick medication made by MSD Animal Health (a division of Merck & Co.). It’s available in two formats:

  • A chewable tablet that protects dogs for 12 weeks
  • A topical solution that also offers 12-week protection

Both formats are designed to kill fleas and ticks from the inside out.

How Does Bravecto Work?

Bravecto’s active ingredient, fluralaner, is part of a group of compounds called isoxazolines. Once administered, the medicine enters your dog’s bloodstream and stays active for weeks or even months, depending on the format.

Here’s what happens next:

  • When a flea or tick bites, it ingests the fluralaner.
  • This compound blocks nerve signals inside the parasite by targeting its GABA-gated and glutamate-gated chloride channels.
  • The result? The flea or tick becomes hyperexcited, then paralyzed, and dies within hours

The key here is sustained systemic protection. With a single chewable, your dog gets up to 12 weeks of coverage, and with the topical version, up to 12 full months—making Bravecto a go-to for long-term parasite control with fewer treatments.

What Is NexGard?

Nexgard chew for dogs 10.1-24 lb kills fleas before they can lay eggs.

NexGard is a monthly beef-flavored chewable made by Boehringer Ingelheim Animal Health. Its active ingredient, afoxolaner, also belongs to the isoxazoline class and works similarly—attacking the nervous system of fleas and ticks to eliminate them fast after they bite.

How Does NexGard Work?

NexGard is a monthly chewable treatment that works quickly once your dog swallows it. Its active ingredient, afoxolaner, also belongs to the isoxazoline family, designed to kill fleas and ticks by disrupting their nervous systems.

Here’s the science made simple:

  • After ingestion, afoxolaner spreads via your dog’s bloodstream.
  • When a flea or tick bites, it consumes the medication and becomes neurologically overactive.
  • This leads to paralysis and death within a short window—fleas typically die within 8 hours, and ticks within 24 to 48 hours.

NexGard works from the inside, so it doesn’t repel parasites—it kills them after they bite. That’s why consistent monthly dosing is essential to avoid any gaps in protection.

Now that you know how Bravecto and NexGard work, it’s time to understand while both belong to the same drug class and follow a similar mechanism to kill parasites, their formulations, dosing schedules, duration of protection, and use cases vary enough to impact your decision - especially when it comes to ease of use, lifestyle fit, and pet sensitivity.

Let’s break down the key similarities and differences to help you confidently choose the right protection for your dog.

What are the Similarities between Bravecto and NexGard?

Bravecto lasts longer with fewer doses. NexGard offers monthly flexibility. Your choice depends on how often you want to treat and how consistent you can be. Let’s break it down:

  • Systemic protection: Both circulate in your dog’s bloodstream. Parasites must bite to ingest the active ingredient and be eliminated.
  • Same drug class: Both use isoxazoline compounds—Bravecto uses fluralaner, and NexGard uses afoxolaner—to target fleas and tick nervous systems.
  • Veterinarian-trusted: Widely recommended and FDA-approved for dogs.
  • Chewable formats: Both are available as chewables, though Bravecto also offers a long-acting topical form

Well, both Bravecto and NexGard are effective killers of ticks, but not all tick preventatives are created equal when it comes to stopping disease transmission.

Let’s take a closer look at which one gives your dog an edge in fighting off tick-borne illnesses—especially Ehrlichia, a growing concern in many regions of the U.S.

Ehrlichia Risk: Which Treatment Offers Better Tick-Borne Disease Protection?

NexGard and Bravecto both reduce the risk of Ehrlichia by killing ticks fast. NexGard has specific studies on blocking transmission. Bravecto limits exposure with long-lasting protection.

Have a look in detail by exploring what is Ehrlichia:

What Is Ehrlichia?

Ehrlichia canis is transmitted by the brown dog tick and can cause serious health problems in dogs like; fever, weight loss, swollen limbs, and in severe cases, even death. 

It’s common in southern U.S. states and is spreading into more regions due to rising temperatures and shifting tick habitats.

Early prevention is key—once a tick attaches and begins to feed, disease transmission can occur in as little as 3–6 hours.

Bravecto vs NexGard: Which Prevents Ehrlichiosis?

  • NexGard has been shown in studies to significantly reduce the transmission of Ehrlichia canis when administered on schedule. Its monthly use ensures consistent tick kills within 24–48 hours, reducing the window in which the pathogen can be transmitted.
  • Bravecto also provides strong protection by killing ticks quickly after they bite. According to a published 12-month field study, dogs treated with Bravecto topical solution had 95% tick-free coverage, which greatly limits the risk of infection.

However, neither product claims to offer absolute “disease-blocking” guarantees. They kill ticks before transmission is likely to occur, not by making your dog immune to Ehrlichia.

Now that we’ve explored how well Bravecto and NexGard defend against dangerous tick-borne diseases like Ehrlichiosis, it’s just as important to ask:

Are these medications safe for pregnant dogs? Let’s break down this so you can feel confident in your choice.

Bravecto vs NexGard Side Effects: Are They Safe for Pregnant or Sensitive Dogs?

Bravecto is FDA-approved and tested safe for pregnant and nursing dogs, with mild side effects. On the other hand, NexGard hasn’t been fully studied in pregnancy; some vets may use it, but it’s best to use it with vet guidance.

Bravecto: Pregnancy-Safe and Well-Studied

  • FDA-approved for use in breeding, pregnant, and lactating dogs, as confirmed by the manufacturer’s site and product labeling (Source)
  • Well-tolerated in MDR‑1 gene-deficient Collies, with no neurological issues at high doses 

Common side effects of Bravecto (rare and mild):

The common side effects of Bravecto include:

  • Vomiting, diarrhea, lethargy, increased thirst.
  • No significant neurological concerns in normal dogs.

NexGard: Unsure for Pregnancy, Proceed with Caution

  • Limited safety data: The standard NexGard formulary states that use in pregnant, breeding, and lactating dogs has not been adequately evaluated, and vets are advised to weigh benefits vs. potential risks (Source).
  • Nevertheless, some veterinarians and regional formulations (e.g., NexGard Spectra) do allow use during pregnancy with vet supervision. (Source)

Common side effects of NexGard (rare and mild):

The common side effects of NexGard include:

  • Occasional vomiting, diarrhea, lethargy
  • Very rare neurological signs (tremors, ataxia, convulsions), often in dogs predisposed to such issues.

Whether you’re choosing Bravecto for its longer duration or NexGard for its monthly flexibility, it helps to know what each option will cost you—and how they compare in terms of long-term value.

Let’s look at the average cost for both medications.

Bravecto vs NexGard Cost: Which One Saves You More in 2025?

If you want fewer treatments per year and slightly lower annual investment, Bravecto chewable or topical solutions may offer better long-term value.

If you prefer spreading out your spending and sticking to a chewable routine NexGard is a predictable monthly expense.

How Much Does Bravecto Cost?

The average cost of Bravecto typically ranges between $25.99 and $80.99, depending on your dog’s weight and whether you choose a monthly chew, a 12-week chewable, or a topical solution.

Bravecto Chewable Tablets (12-Week Protection):

Bravecto Monthly Chews (1-Month Protection):

Bravecto Topical Solutions (12-Week Protection):

[Note: Actual pricing may vary over time. Please check the product page for the most up-to-date pricing information.]

Topical Bravecto may be a good choice for dogs that are picky with chews or have dietary restrictions

How Much Does NexGard Cost?

The average cost of NexGard typically ranges between $29 to $31, depending on various factors like weight, lifestyle, etc.

[Note: Actual pricing may vary over time. Please check the product page for the most up-to-date pricing information.]

While cost plays a major role in choosing the right flea and tick prevention, it’s just one piece of the puzzle. The effectiveness and safety of Bravecto or NexGard can vary depending on your dog’s breed, size, and genetic sensitivity—especially when it comes to breeds with known drug sensitivities like Collies or Shelties. 

To make a fully informed decision, it’s important to consider how different breeds typically respond to each treatment.

Breed-Specific Considerations: Which Dogs Do Best on Bravecto or NexGard?

Bravecto has been tested in Collies with the MDR1 gene. NexGard works well for small dogs and picky eaters. Large breeds often benefit from Bravecto topical solutions for year-round ease.”

Let’s break down what you need to know based on breed and size.

MDR1 Gene Sensitivity: What It Means

Certain breeds—especially herding dogs—may carry the MDR1 mutation, which affects how their bodies process certain drugs. While Bravecto and NexGard are generally well tolerated, extra caution is advised.

Breeds commonly affected:

  • Collies
  • Australian Shepherds
  • Border Collies
  • Shelties (Shetland Sheepdogs)

Which Dogs Typically Do Well on Each Treatment?

Breed Type

Better Tolerated Product

Notes

Toy & small breeds

NexGard

A monthly chewable format makes dosing easier in smaller bodies

Large & giant breeds

Bravecto (topical or chewable)

Year-long protection reduces owner error and missed doses

Herding breeds (MDR1+)

Bravecto (field tested)

Safe at high doses in studies, though vet monitoring still advised

Allergy-prone breeds

Case-dependent

Try switching if mild GI side effects occur with either option

Can You Switch Between Bravecto and NexGard? Transition Tips for Seasonal & Sensitive Dogs 

Yes, you can switch between Bravecto and NexGard. Just don’t overlap doses and talk to your vet before making the change - especially if your dog has had side effects.

Here’s how to know when it’s the right move—and how to do it without exposing your dogs in peak fla tick season. 

When Should You Consider Switching Between Bravecto and NexGard?

  • You’ve missed a dose of NexGard and want year-round coverage with fewer treatments.
  • Your dog had side effects from one product and needs a different formulation.
  • You’re moving to or living in a region with year-round tick risk (like the South).
  • You want to implement a treatment rotation strategy to avoid resistance buildup.

Vets sometimes advise rotating flea and tick medications every 6 to 12 months to help prevent parasites from developing resistance—especially in high-risk areas or multi-dog homes.

Regional Risk Tip: Where You Live Shapes Your Plan

  • In Southern states like Florida and Texas, where fleas and ticks are active nearly all year, many vets prefer Bravecto topical or chewable formats for uninterrupted protection.
  • In Northern or temperate climates, NexGard may be used during the warm months and paused during winter—making it a good fit for seasonal tick coverage.

Switching from NexGard to Bravecto in spring, then back in fall (or vice versa) is a common seasonal rotation strategy that balances protection and cost.

Safe Switching Checklist

  • Don’t overlap doses. Wait until the current product’s coverage period ends before starting the new one.
  • Consult your vet—especially if switching due to side effects or if your dog has a health condition.
  • Monitor for reactions in the first 24–48 hours after switching.

Now that you understand when and why to switch, let’s break down the core differences that matter most when deciding between these two top flea and tick treatments.

Difference Between Bravecto and NexGard

The main difference between Bravecto and NexGard is the duration of protection. Bravecto protects dogs for up to 12 weeks with one dose, while NexGard requires monthly dosing. Bravecto also offers topical formats, whereas NexGard is only available as a chewable tablet.

Let's Compare Key Features of each Side by Side:

Final Verdict: Should You Choose Bravecto or NexGard in 2025?

After breaking down Bravecto vs NexGard across safety, duration, pricing, and breed-specific needs—it’s clear that there’s no one-size-fits-all answer. The best choice depends on your dog, your region, and your routine.

Here’s a quick decision guide to help you make the call:

Choose Bravecto if:

✅ You want fewer treatments per year
✅ You prefer topical or quarterly chewables
✅ You live in a high-risk tick area year-round
✅ You have a large breed or struggle with monthly compliance
✅ Your dog is pregnant, nursing, or MDR1-sensitive

Choose NexGard if:

✅ You prefer monthly chewable flexibility
✅ Your dog is small, picky, or sensitive to injectable meds
✅ You live in a seasonal flea/tick region
✅ You’re switching from another monthly isoxazoline
✅ You want to rotate treatments regularly

Still Unsure?

HardyPaw makes it easy to explore, compare, and order trusted flea and tick treatments like Bravecto,NexGard, Simparica Trio, andTrifexis—all in one convenient platform. 

Our product listings include transparent pricing, format options, and vet-approved information so you can choose the right protection based on your dog’s unique needs and lifestyle.

NexGard vs Bravecto FAQs

Can Bravecto and NexGard be used with heartworm medication?

Yes, both Bravecto and NexGard can be safely used alongside heartworm preventatives like Heartgard or Interceptor. Always confirm compatibility with your vet.

Does NexGard protect against mites or mange?

Yes, NexGard is FDA-approved for treating sarcoptic mange caused by mites. Bravecto also has demonstrated efficacy in managing certain types of mange.

Can Bravecto or NexGard cause seizures?

Isoxazolines like Bravecto and NexGard may cause seizures in rare cases, especially in dogs with a history of neurological disorders. Always consult your vet.

Do Bravecto or NexGard require a prescription?

Yes, both Bravecto and NexGard are FDA-regulated and require a valid veterinary prescription to purchase in the U.S., regardless of format.

Can I alternate Bravecto with Simparica Trio or other meds?

Yes, rotating Bravecto with Simparica Trio or similar products may help reduce resistance. Always allow the full coverage period to lapse before switching.

Which Flea Treatment Kills Ticks Faster: Bravecto or NexGard?

Bravecto kills ticks within approximately 12 hours, while NexGard kills ticks within 24–48 hours. Bravecto acts faster overall, offering quicker tick elimination in most cases.

Which Flea Treatment Costs Less: Bravecto or NexGard?

Bravecto typically costs less annually because one chew lasts up to 12 weeks, reducing the number of doses. NexGard, as a monthly treatment, results in a higher yearly cost despite lower per-dose pricing.

Which Flea Treatment Is Best for MDR1-Sensitive Breeds?

Bravecto is tested and shown to be safe for MDR1-sensitive breeds like Collies and Australian Shepherds. NexGard should be used cautiously and only under veterinary supervision in these dogs.

References Used:

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