Zenrelia (ilunocitinib tablets) for Dogs, 6.4-mg

Fast Relief for Allergic Itch in Dogs

Product Description

Zenrelia ilunocitinib tablets are a once daily oral immunomodulator for dogs at least 12 months old, used for controlling pruritus associated with allergic dermatitis and atopic dermatitis. As a Janus kinase inhibitor, it targets cytokines involved in itch and inflammation without being a corticosteroid or antihistamine. Available in multiple strengths for accurate weight-based dosing.

Product may arrive in a Hardy Paw Pharmacy vial, manufacturer packaging is shown for reference.

Benefits

• Targets Itch Pathways: Inhibits JAK1, JAK2, and TYK2 to reduce pruritogenic and pro-inflammatory cytokine signaling.
• Once Daily Dosing: Administered orally once daily at 0.6 to 0.8 mg/kg, with or without food.
• Proven Effectiveness: Demonstrated significantly higher treatment success versus placebo in controlled clinical field studies.
• Multiple Strengths: Available in four scored tablet strengths to support accurate weight-based dosing.
• Non Steroidal Option: Not classified as a corticosteroid or antihistamine for itch management.

Ingredients

Active Ingredients

Ilunocitinib

How to Use

Recommended-Dosage Chart

Dosage & Administration Instructions

• Once Daily Dose: Administer 0.6 to 0.8 mg/kg orally once daily as prescribed by the veterinarian.
• With or Without Food: Tablets may be given with food or on an empty stomach.
• Weight-Based Dosing: Select tablet strength according to the body weight dosing chart provided by the manufacturer.
• Prescription Only: Federal law restricts use by or on order of licensed veterinarian.

Disclaimer: This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any supplement for your pet.

Additional Information

Precautions

• Vaccination Timing: Discontinue 28 days to 3 months before vaccination and withhold 28 days after.
• Infection Risk: Monitor dogs for opportunistic infections, including demodicosis, pneumonia, and urinary tract infections.
• Serious Infections: Not for use in dogs with existing serious infections.
• Young Dogs: Not for use in dogs less than 12 months of age.
• Reproductive Safety: Safe use not evaluated in breeding, pregnant, or lactating dogs.

Possible Side Effects

• Gastrointestinal Signs: Clinical studies reported vomiting, diarrhea, loss of appetite, and signs of abdominal discomfort.
• Lethargy: Some dogs showed lower activity levels during field studies.
• Elevated Liver Enzymes: Safety evaluations noted increases in liver-related values.
• Blood Abnormalities: Reports included leukopenia, neutropenia, and reduced red blood cell counts.
• Urinary Infections: Urinary tract infections were observed in clinical field studies.

Storage Information

• Room Temperature: Store between 15 and 25 degrees Celsius.
• Temperature Excursions: Excursions permitted between 5 and 40 degrees Celsius.
• Secure Storage: Keep in a secure location out of reach of pets and other animals.

Shipping & Return  

We offer ground, express, priority, and international delivery; see our shipping policy for details.  

For return instructions or product concerns, please refer to our detailed refund policy.   

Prescription items are NON-RETURNABLE and NON-REFUNDABLE.  

Frequently Asked Questions

Q1: What is Zenrelia used for in dogs?

Ans: Zenrelia is used to relieve itching in dogs diagnosed with allergic dermatitis or atopic dermatitis. It works by blocking Janus kinase enzymes that help drive the inflammatory response and the signals responsible for itch.

Q2: How is Zenrelia dosed for dogs?

Ans: Zenrelia is administered orally once daily in an amount of 0.6 to 0.8 mg/kg, which equals 0.27 to 0.36 mg per pound of body weight. Tablets may be given with or without food according to the veterinarian’s instructions.

Q3: Can my dog receive vaccines while taking Zenrelia?

Ans: Dogs treated with Zenrelia should not be vaccinated while on the medication. Because it can affect the immune system, there is a higher risk of vaccine-related illness with modified live vaccines and a reduced ability to develop proper immunity.

Zenrelia should be discontinued 28 days to 3 months before any vaccination. After the vaccine is given, wait at least 28 days before restarting treatment.

Q4: What are the common side effects of Zenrelia in dogs?

Ans: Possible side effects can include vomiting, diarrhea, fatigue, decreased appetite, urinary tract infections, elevated liver enzymes, and changes in blood work. These changes may involve low white blood cell counts, including leukopenia and neutropenia. Dogs receiving this treatment should be carefully monitored for any signs of infection, as well as any unusual lab results that may appear during therapy.

Q5: Is Zenrelia a steroid or an antihistamine?

Ans: Zenrelia is not a corticosteroid or an antihistamine. It is a synthetic Janus kinase inhibitor that modulates the immune response by blocking cytokines involved in pruritus and inflammation associated with allergic and atopic dermatitis in dogs.