Zenrelia (ilunocitinib tablets) for Dogs, 4.8-mg

Fast Itch Relief for Allergic Dogs

Product Description

Zenrelia is a prescription oral medication designed for dogs 12 months and older to help manage itching linked to allergic dermatitis and atopic dermatitis. This once-daily tablet works by targeting the immune pathways that drive itch and inflammation. By addressing the source of discomfort it helps improve your dog’s comfort through a simple, vet-prescribed daily routine.

Product may arrive in a Hardy Paw Pharmacy vial; manufacturer packaging is shown for reference.

Benefits

• Supports Itch Control: Helps ease itching associated with atopic and allergic dermatitis in dogs 12 months and older.
• Daily Oral Use: Given once a day in an easy-to-administer tablet that can be taken with or without food.
• Trusted JAK Inhibitor: Contains ilunocitinib, a non-selective JAK inhibitor that targets the inflammation linked to itching.
• Veterinarian Prescribed: Available by prescription only, so treatment is guided by a licensed veterinarian for safe and appropriate use.
• Multiple Tablet Strengths: Comes in a range of strengths to allow accurate dosing based on your dog’s weight.

Ingredients

Active Ingredients

Ilunocitinib (4.8 mg) 

How to Use

Recommended-Dosage Chart

Dosage & Administration Instructions

• Once Daily Dosing: Give 0.6 to 0.8 mg per kg of body weight by mouth once a day.
• With or Without Food: Tablets can be given with a meal or on an empty stomach.
• Weight-Based Selection: Choose the appropriate tablet strength and number of tablets based on your dog’s current weight.
• Prescription Only: Federal law limits this medication to use by, or on the order of, a licensed veterinarian.

Disclaimer: This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any supplement for your pet.

Additional Information

Precautions

• Vaccination Restriction: Discontinue 28 days to 3 months before vaccination and withhold 28 days after.
• Monitor Infections: May increase susceptibility to opportunistic infections, including demodicosis and pneumonia.
• Serious Infections: Not for use in dogs with serious or uncontrolled infections.
• Minimum Age Limit: Not for use in dogs younger than 12 months.
• Immunosuppressive Effects: Modulates the immune system and may reduce vaccine response.

Possible Side Effects

• Digestive Issues: In clinical trials, the most commonly reported side effects were vomiting, feeling sick to the stomach, and diarrhea.
• Low Energy: Some dogs experienced a drop in their usual energy levels and appeared tired or less active while receiving treatment.
• Changes in Blood Levels: A reduction in hematocrit, hemoglobin, and red blood cell counts was noted in certain cases.
• Liver Test Results: There were reports of increased liver enzyme levels, including ALT and AST, during the course of treatment.
• Higher Risk of Infections: The treatment was linked to a greater chance of developing infections, including bacterial, fungal, and respiratory infections.

Storage Information

• Room Temperature: Store at 15°C to 25°C or 59°F to 77°F.
• Temperature Excursions: Short-term exposure between 5°C and 40°C is permitted when needed.
• Secure Storage: Keep in a safe place out of reach of pets and children.

Shipping & Return 

We offer ground, express, priority, and international delivery; see our shipping policy for details. 

For return instructions or product concerns, please refer to our detailed refund policy.  

Prescription items are NON-RETURNABLE and NON-REFUNDABLE.   

Frequently Asked Questions

Q1: What is Zenrelia used for in dogs?

Ans: Zenrelia is used for the control of severe itching caused by atopic and allergic dermatitis in dogs at least 12 months of age. It works by inhibiting Janus kinase pathways involved in inflammation and itching.

Q2: How is Zenrelia administered to dogs?

Ans: Zenrelia is administered orally once daily, around 0.6 to 0.8 mg/kg body weight. It may be given with or without food. Tablet strength and quantity are selected based on the dog’s current weight.

Q3: Can dogs receive vaccines while taking Zenrelia?

Ans: Dogs receiving Zenrelia should not be vaccinated due to the risk of vaccine-induced disease and inadequate immune response. Treatment should be discontinued 28 days to 3 months before vaccination and withheld for at least 28 days after vaccination.

Q4: What are the most common side effects of Zenrelia?

Ans: Commonly reported adverse reactions include vomiting, diarrhea, lethargy, urinary tract infections, and elevated liver enzymes. Hematologic changes, such as decreased red blood cell counts, have also been observed in clinical studies.

Q5: Is Zenrelia safe for puppies or breeding dogs?

Ans: Zenrelia is not approved for dogs younger than 12 months of age. The safety of Zenrelia has not been evaluated in breeding, pregnant, or lactating dogs. A veterinarian should assess risks before initiating treatment.