Veterinary Periodontal Treatment Gel for Canines

Product Description

DOXIROBE Gel is a formulation of doxycycline hyclate that veterinarians use for managing and treating periodontal disease in dogs. It is administered directly into periodontal pockets that are 4 mm deep or more, offering continuous local antimicrobial effects against bacteria linked to periodontal disease. The biodegradable polymer sets in position and slowly releases doxycycline, enhancing attachment levels and decreasing pocket depth within a time frame of 2 to 4 weeks.

Benefits

• Localized Antibiotic Action: Delivers doxycycline directly into periodontal pockets for targeted antimicrobial effect against gram-negative anaerobic bacteria.
• Sustained Drug Release: The polymer delivery system hardens within the pocket and slowly releases doxycycline for ongoing local efficacy.
• Biodegradable Formula: Creates a solid, flexible matrix that does not need to be extracted during subsequent visits.
• Clinically Proven: Clinical studies demonstrated increases in attachment levels, a decrease in pocket depth, and enhanced gingival health.
• Low Systemic Exposure: Detectable plasma concentrations remained below levels associated with systemic activity or toxicity.

Ingredients

Composition Table

Other Ingredients

N-methyl-2-pyrrolidone, poly DL lactide

How to Use

Recommended-Usage Chart

Dosage & Administration Instructions

• Veterinary Prescription Only: This medication is limited by federal law to administration by or under the direction of a licensed veterinarian.
• Pre-Clean Teeth: Perform scaling and cleaning prior to gel application to ensure proper periodontal pocket preparation.
• Mix Thoroughly: Exchange materials between Syringe A and Syringe B approximately 100 times for a consistent mixture.
• Subgingival Placement: Insert a blunt cannula 1 to 2 mm below the gingival margin before expressing gel.
• Fill Pockets Fully: Express gel into periodontal pockets 4 mm or deeper up to the gingival margin.
• Allow Hardening: Permit the polymer to solidify for 30 to 60 seconds before pressing it into the pocket.

Disclaimer: This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any supplement for your pet.

Additional Information

Precautions

• Young Dogs Warning: Do not use in dogs under one year due to the risk of permanent tooth discoloration.
• Pregnancy Restriction: Avoid use in pregnant bitches as safety during pregnancy has not been established.
• Breeding Dogs: The safety of this product has not been assessed in breeding dogs.
• Suspend Brushing: Inform clients to refrain from brushing the treated teeth for about two weeks following the treatment.
• Not For Certain Lesions: This product is not suitable for oronasal fistulas, periapical abscesses, or teeth that are severely compromised.

Possible Side Effects

• Low Systemic Exposure: Measurable plasma levels of doxycycline were lower than those known to cause systemic toxicity.
• Localized Reaction Potential: Similar to periodontal procedures, localized reactions at the application site might occur after subgingival delivery.

Storage Information

• Room Temperature Storage: Store at controlled room temperature between 15° and 30°C.
• Reconstituted Product Use: Store mixed product at 15° to 25°C and use within three days.
• Additional Mixing Required: Perform ten additional syringe exchanges if stored after initial mixing.

Shipping & Return

We offer ground, express, priority, and international delivery; see our shipping policy for details.

For return instructions or product concerns, please refer to our detailed refund policy. 

Prescription items are NON-RETURNABLE and NON-REFUNDABLE.

Frequently Asked Questions

Q1: What is DOXIROBE Gel used for in dogs?

Ans: DOXIROBE Gel is indicated for the treatment and control of periodontal disease in dogs. It is applied into periodontal pockets 4 mm or deeper, where it releases doxycycline locally to target bacteria associated with periodontal disease and improve gingival health within 2 to 4 weeks.

Q2: How does DOXIROBE Gel work inside the periodontal pocket?

Ans: After being mixed, the gel is applied below the gum line, solidifying upon contact with the gingival crevicular fluid. This forms a biodegradable structure that gradually releases doxycycline into the periodontal pocket, providing targeted antimicrobial action against the gram-negative anaerobic bacteria linked to periodontal disease.

Q3: Does DOXIROBE Gel cause systemic antibiotic effects?

Ans: In clinical studies, the peak plasma levels of doxycycline were observed six hours post-administration and remained beneath the thresholds linked to systemic effects or toxicity. Plasma samples showed no doxycycline presence at 24 hours or beyond, suggesting limited systemic exposure.

Q4: Does DOXIROBE Gel need to be removed after treatment?

Ans: Gel removal is not mandatory. The polymer delivery system solidifies within the periodontal pocket and is biodegradable. As it gradually breaks down, it continues releasing doxycycline locally, eliminating the need for a follow-up visit to remove the material.

Q5: Can DOXIROBE Gel be used in all dogs?

Ans: DOXIROBE Gel should not be used in dogs less than one year of age due to the risk of permanent tooth discoloration associated with tetracyclines. It is also not recommended for pregnant dogs, and safety has not been evaluated in breeding dogs.