Simplicef (cefpodoxime proxetil) Tablets - Antibiotic for Dogs

Once Daily Skin Infection Treatment for Dogs

Product Description

SIMPLICEF Chewable Tablets are a veterinarian-prescribed oral antibiotic for skin infections like wounds,abscesses in dogs caused by susceptible bacteria. Formulated with cefpodoxime proxetil, this FDA-approved medication delivers broad-spectrum bactericidal activity in an easy-to-administer chewable form. Give once a day with or without food to support effective treatment outcomes.

Please note that the product may arrive in a Hardy Paw Pharmacy vial; manufacturer packaging is shown for reference.

Benefits

• Convenient Once Daily: Administered once every 24 hours to help support treatment compliance for your dog.
• Broad Spectrum: Targets a range of susceptible bacteria responsible for common canine skin infections.
• Bactericidal Action: Works by disrupting bacterial cell wall synthesis to help eliminate infection.
• Chewable Form: Scored chewable tablets are easier to give to dogs than conventional tablets.
• Veterinary Proven: Backed by research and approved under FDA NADA # 141-232 for canine use.

Variants

100 mg Chewable Tablets

200 mg Chewable Tablets

Ingredients

Active Ingredients

Cefpodoxime proxetil (equivalent to cefpodoxime) 100 mg or 200 mg per tablet.

How to Use

Recommended Dosage Chart

5 mg/kg Total Daily Dosage

10 mg/kg Total Daily Dosage

Disclaimer: This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any supplement for your pet.
Source:

Additional Information

Precautions

• Allergic Sensitivity: Do not use in dogs with known hypersensitivity to cephalosporins or penicillins.
  Breeding Safety: Safety has not been demonstrated in breeding, pregnant, or lactating dogs.
• Coombs Test: May occasionally induce a positive direct Coombs test result.
• Handler Precaution: Avoid direct skin or mucous membrane contact to reduce allergic reaction risk.

Possible Side Effects

• Vomiting: Reported in clinical field studies among dogs receiving cefpodoxime therapy.
• Diarrhea: Mild gastrointestinal upset observed in a small number of treated dogs.
• Decreased Appetite: Reduced food intake noted in isolated cases during clinical evaluation.
• Increased Thirst: Increased water consumption observed in dogs receiving active control during studies.

Storage Information

• Room Temperature: Store at controlled room temperature between 20 and 25 degrees Celsius.
• Excursion Range: Permitted temperature excursions range between 15 and 40 degrees Celsius.
• Secure Container: Replace the cap securely after each opening to maintain product integrity.

Shipping & Return

We offer ground, express, priority, and international delivery; see our shipping policy for details.

For return instructions or product concerns, please refer to our detailed refund policy. 

Prescription items are NON-RETURNABLE and NON-REFUNDABLE.  

Frequently Asked Questions

Q1: What is SIMPLICEF Chewable used for in dogs?

Ans: SIMPLICEF Chewable Tablets are indicated for treating canine skin infections, including wounds and abscesses, caused by susceptible bacteria such as Staphylococcus pseudintermedius, Staphylococcus aureus, Streptococcus canis, Escherichia coli, Pasteurella multocida, and Proteus mirabilis. It is approved for oral use in dogs only.

Q2: How often should SIMPLICEF be given to dogs?

Ans: SIMPLICEF is administered orally 5 to 10 mg per kilogram of body weight once daily. Treatment typically continues for 5 to 7 days or 2 to 3 days beyond clinical resolution, not exceeding 28 days.

Q3: Can SIMPLICEF be given with food?

Ans: SIMPLICEF Chewable Tablets may be administered with or without food. Co-administration with food has been shown to increase the oral bioavailability of cefpodoxime, the active metabolite, potentially enhancing systemic exposure without changing the recommended dosing schedule.

Q4: What are the possible side effects of SIMPLICEF in dogs?

Ans: In clinical field studies, reported adverse reactions included vomiting, diarrhea, decreased appetite, and increased water consumption. These effects were observed in a small number of dogs and were generally mild. Contact your veterinarian if unusual symptoms occur.

Q5: Is SIMPLICEF safe for puppies or breeding dogs?

Ans: Target animal safety studies demonstrated tolerance at labelled doses in adult dogs and puppies. However, safety has not been established for dogs used for breeding, pregnant dogs, or lactating bitches. Consult your veterinarian before use in these populations.