Dantrolene Capsules, 100mg

Dantrolene Capsules for Equine and Canine Muscle Disorders

Dantrolene capsules are an effective prescription muscle relaxant widely used in veterinary medicine to manage exertional rhabdomyolysis (ER) and post-anesthetic myositis (PAM) in horses. This potent medication works by inhibiting calcium release from the sarcoplasmic reticulum in skeletal muscles, promoting muscle relaxation and preventing muscle damage caused by excessive contraction. Additionally, Dantrolene is often prescribed to treat functional urethral obstruction in dogs and cats, making it a versatile choice for pets with specific muscle-related conditions.

All prescription items are Non-Refundable and Non-Returnable.

NOTE: For generic medications, picture displayed may not depict actual product. Generic medications may vary from one order to the next by size, color and shape depending on manufacturer. Please note product may arrive in a Hardy Paw Pharmacy vial.

What Are the Benefits of Dantrolene Capsules?

1. Targeted Muscle Relaxation: Prevents and treats painful muscle spasms and stiffness in horses suffering from ER or PAM.
2. Versatile Use Across Species: Effective in managing urethral obstructions in both dogs and cats.
3. Improved Recovery After Anesthesia: Reduces risks of muscle damage associated with post-anesthetic myositis in equines.
4. Proven Mechanism of Action: Regulates calcium levels in skeletal muscles, preventing over-contraction and associated tissue damage.

How to Use Dantrolene Capsules for Optimal Results?

Always consult your veterinarian before administering Dantrolene. Dosage and frequency will depend on your pet's specific condition and body weight.

• Horses: Typically prescribed for conditions like ER and PAM.
• Dogs and Cats: Dosage varies for functional urethral obstruction; follow your vet's recommendations carefully.

What Ingredients Are in Dantrolene Capsules?

Each capsule contains:

• Active Ingredient: Dantrolene Sodium 100mg
• Inactive Ingredients: Microcrystalline cellulose, gelatin, titanium dioxide, and other capsule excipients.

Are There Any Side Effects of Dantrolene?

While generally well-tolerated, Dantrolene may cause side effects in some animals. Common side effects include:

• Drowsiness
• Muscle weakness
• Loss of appetite
• Digestive upset (e.g., diarrhea or nausea)

Note: If any severe reactions occur, such as difficulty breathing or significant muscle weakness, discontinue use and contact your veterinarian immediately.

What Precautions Should You Take with Dantrolene?

• Avoid Use in Pregnant Animals: Consult your vet for alternatives if your pet is pregnant.
• Monitor Liver Health: Prolonged use may require regular liver function tests to rule out hepatotoxicity.
• Proper Storage: Store in a tightly closed container, away from moisture, light, and heat.

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FAQs - Dantrolene Capsules muscle-related disorders

What is Dantrolene Capsules used for?

Dantrolene Capsules are used to treat muscle-related disorders in animals, including exertional rhabdomyolysis and post-anesthetic myositis in horses, as well as functional urethral obstruction in dogs and cats. The medication promotes muscle relaxation by regulating calcium release in skeletal muscles, preventing over-contraction and tissue damage.

How does Dantrolene work in the body?

Dantrolene works by inhibiting calcium release from the sarcoplasmic reticulum within skeletal muscle cells. This action reduces muscle contractions, relieving spasms, and preventing conditions like muscle stiffness and breakdown, which are common in exertional rhabdomyolysis and other muscle-related disorders.

Can Dantrolene be used for long-term treatment?

Dantrolene can be used for long-term treatment under veterinary supervision, but regular monitoring is essential. Prolonged use may affect liver function, so veterinarians may recommend periodic blood tests to assess liver health and ensure the safety and effectiveness of the medication.

Is Dantrolene effective for treating malignant hyperthermia?

Yes, Dantrolene is widely used in veterinary and human medicine to manage malignant hyperthermia. It prevents excessive calcium buildup in muscles, which is a hallmark of the condition, helping to stabilize body temperature and reduce muscle rigidity. Consult your veterinarian for specific dosing instructions.

What should I do if my pet misses a dose of Dantrolene?

If your pet misses a dose of Dantrolene, administer it as soon as you remember. However, if it is close to the time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Never give a double dose to make up for a missed one.

Are there alternatives to Dantrolene for muscle disorders?

Yes, alternative muscle relaxants or treatments may be available depending on your pet's specific condition. Options include methocarbamol or physical therapy. Always consult your veterinarian for recommendations tailored to your pet's health needs.

Can Dantrolene be given alongside other medications?

Dantrolene can interact with certain medications, such as other muscle relaxants, anesthetics, or medications that affect liver enzymes. Inform your veterinarian of all medications your pet is taking to avoid potential interactions and ensure safe administration.

How quickly does Dantrolene start working?

Dantrolene typically begins to take effect within 2 to 4 hours of administration, with muscle relaxation becoming more noticeable over time. For conditions like exertional rhabdomyolysis, the duration of treatment may vary based on the severity of symptoms.

Is Dantrolene safe for all breeds of dogs and horses?

Dantrolene is generally safe for most breeds when used under veterinary supervision. However, factors such as age, underlying health conditions, and liver function may influence its suitability. Always consult your veterinarian to determine if it is safe for your specific pet.

What happens if Dantrolene is accidentally overdosed?

Overdosing on Dantrolene may cause severe side effects such as extreme muscle weakness, drowsiness, or liver toxicity. If an overdose is suspected, seek immediate veterinary assistance. Your vet may recommend supportive care to address symptoms and prevent complications.

Clinical Research: 

https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/017443s043s046s048s049lbl.pdf

https://www.tga.gov.au/resources/section-19a-approvals/dantrium-dantrolene-sodium-25mg-capsules-norgine