Trifexis Chewable Tablets for Dogs 40.1-60 lbs (Spinosad + Milbemycin Oxime)

Trifexis for Dogs 40.1-60 lbs

Comprehensive Flea, Heartworm & Intestinal Parasite Protection

What is Trifexis for Dogs 40.1-60 lbs?

Trifexis for Dogs 40.1-60 lbs is a veterinary-recommended, beef-flavored chewable tablet that provides broad-spectrum parasite protection for medium-sized dogs. This once-a-month tablet safeguards your pet against fleas, heartworm disease, and common intestinal parasites like roundworms, hookworms, and whipworms.

By combining spinosad and milbemycin oxime, Trifexis ensures fast-acting flea elimination and ongoing parasite prevention, keeping your dog healthy and free from infestations.

Prescription items are NON-RETURNABLE and NON-REFUNDABLE.

Please note that the product may arrive in a Hardy Paw Pharmacy vial, manufacturer packaging is shown for reference.

Also Available in Different Weight Ranges

Trifexis is available in multiple dosage strengths to ensure the best protection for dogs of all sizes. Choose the right option based on your dog's weight:

📌 Trifexis for Dogs 5-10 lbs (Magenta)
📌 Trifexis for Dogs 10.1-20 lbs (Orange)
📌 Trifexis for Dogs 20.1-40 lbs (Green)
📌 Trifexis for Dogs 40.1-60 lbs (Blue)  (you are viewing this product)
📌 Trifexis for Dogs 60.1-120 lbs (Brown)  

Ensure your dog gets the correct Trifexis dosage based on their weight for optimal protection against fleas, heartworms, and intestinal parasites! 🐶💊

What Are the Benefits of Trifexis for Dogs 40.1-60 lbs?

• Triple Protection in One Tablet – Prevents heartworm disease, kills fleas before they lay eggs, and treats intestinal parasites.
  
• Fast-Acting Flea Control – Starts killing fleas within 30 minutes and eliminates 100% of fleas in 4 hours.
  
• No Messy Topicals – Unlike spot-on treatments, Trifexis is an oral chewable, eliminating the risk of residue on your dog's coat.
  
• Long-Lasting Monthly Dosage – One tablet provides 30 days of continuous protection against multiple parasites.
  
• Prevents Reinfestation – Effectively disrupts the flea life cycle by killing adult fleas before they reproduce.
  
• Vet-Approved Protection – Clinically tested and recommended by veterinarians for comprehensive parasite prevention.

How to Administer Trifexis for Dogs 40.1-60 lbs?

• Give one chewable tablet orally once a month.
  
• Administer with food to enhance absorption and effectiveness.
  
• Continue treatment year-round for consistent flea and parasite prevention.
  
• If a dose is missed, administer it immediately and resume the monthly schedule.
  
• Consult your vet before starting Trifexis, especially if your dog has a history of seizures or pre-existing health conditions.

How to Help a Dog Who Doesn't Like Taking Pills?

For picky eaters, swallowing a pill can be challenging. Offer solutions like:

• Hiding in a treat (peanut butter, cheese, or pill pockets)
• Crushing and mixing with food (consult a vet first)
• Using a pill dispenser for easy swallowing

What Are the Active Ingredients in Trifexis?

How Does Trifexis Work to Protect Your Dog?

Break down the mechanism of action for each active ingredient:

• Spinosad (Flea Control):
  • Disrupts the nervous system of fleas, leading to paralysis and rapid death.
  • Starts working within 30 minutes and eliminates 100% of fleas in 4 hours.
• Milbemycin Oxime (Heartworm & Intestinal Parasites):
  • Interferes with nerve transmission in heartworm larvae (Dirofilaria immitis), preventing them from developing into adult worms.
  • Eliminates hookworms, roundworms, and whipworms by disrupting their neuromuscular function.

What to Expect After Giving Trifexis?

Help pet owners understand what’s normal after administering Trifexis:

🕐 First 30 minutes: Fleas begin dying; some may become more visible before falling off.
🕒 Within 4 hours: Full flea elimination.
🌙 24-48 hours: No live fleas should be present.
📆 Ongoing: Parasite protection continues for 30 days.

Are There Any Side Effects of Trifexis for Dogs?

Most dogs tolerate Trifexis well, but some may experience mild side effects such as:

• Vomiting (most common)
• Lethargy or decreased activity
• Loss of appetite
• Diarrhea
• Itching or skin irritation

💡 Important: If severe reactions like seizures, difficulty breathing, or persistent vomiting occur, contact your veterinarian immediately.

What Precautions Should You Take When Using Trifexis?

⚠ Not for puppies under 8 weeks or under 5 lbs.
⚠ Safe use in pregnant or breeding dogs has not been evaluated.
⚠ Do not administer to dogs with a history of neurological disorders without consulting your vet.
⚠ Keep out of reach of children and store at room temperature.

Subscription & Auto-Refill Benefits

🔔 Never Miss a Dose! Subscribe & Save on Trifexis with HardyPaw for automatic deliveries & exclusive discounts.

Shipping & Returns 

Shipping Policy: HardyPaw offer all types of shipping options (Ground, Express, Priority, International) depending on the urgency of the product requirements. To know about our shipping policy in detail, click here.

Refund policy: If you face any issue with our product and want to return it, read our refund policy carefully.

Trifexis for Dogs 40.1-60 lbs FAQs

What is Trifexis used for?

Trifexis is a monthly oral chewable that prevents heartworm disease, kills fleas, and treats intestinal parasites (hookworms, roundworms, and whipworms) in dogs weighing 40.1-60 lbs.

How long does it take for Trifexis to start working?

Trifexis starts killing fleas within 30 minutes, with 100% elimination within 4 hours. It also begins preventing heartworm and intestinal parasites as soon as it's ingested.

Can I give Trifexis to my dog without food?

No. Trifexis should always be given with food to maximize its effectiveness and reduce the chance of stomach upset.

Does Trifexis protect against ticks?

No, Trifexis does not offer tick protection. For tick control, consider using an additional tick-preventive product recommended by your vet.

What should I do if my dog vomits after taking Trifexis?

If vomiting occurs within one hour of administration, give another full dose. If vomiting persists, consult your veterinarian.

High Authority References:

🔗 Understanding Heartworm Disease – American Heartworm Society

🔗 Flea Lifecycle & Prevention – American Veterinary Medical Association (AVMA)

🔗 Pet Parasite Prevention Guide – Companion Animal Parasite Council (CAPC)