Cyclavance Oral Solution For Dogs

Cyclavance, an oral solution containing cyclosporine, is designed to provide specialized support for the immune systems of pets. The convenient liquid form makes it a great option for pets who struggle to swallow pills or capsules, providing a stress-free experience. Its rapid uptake enables swift incorporation into your pet's body, giving immediate immune assistance. Cyclavance is relied upon by veterinarians for its effectiveness in treating a range of immune-related conditions due to its versatility. Cyclavance is a comprehensive solution whether it's for allergies, autoimmune diseases, or helping with organ transplants. It remains safe for extended use, providing continuous assistance for pets experiencing chronic immune problems. Every bottle comes with a handy dropper for accurate dosage control.

• 4 presentations are available for use with various weights of dogs or cats depending on how often treatments are needed.
• 2 different sizes of syringes are available and they can provide accurate measurements to the closest kilogram for both dogs and cats of any size.
• The Adaptor Cap design allows bottles to remain sealed for a complete 6 months.
• After clinical symptoms are adequately managed, the frequency of treatment can be decreased to every second day or twice a week.
• Cyclavance in its liquid form enables precise dosing to the nearest kilogram with a single easy application, reducing the chances of under or overdosing effectively.
• Cap Adaptor - Comes with a valve for convenient and secure storage and a shelf life of 6 months.
• Luer Lock - Syringe and Adaptor Cap prevent leaks and product loss.
• 100mg/ml - Conveniently small size for easier giving of medicine.
• There is more than a decade of safety data backing the use of Ciclosporin in atopic dogs.

Prescription items are NON-RETURNABLE and NON-REFUNDABLE.

Please note product may arrive in a Hardy Paw Pharmacy vial, manufacturer packaging is shown for reference.

Dosage and Administration

Always provide the instructions for assembling the dispensing system and preparing a dose of CYCLAVANCE and the information for dog owners with the prescription. The initial dose of CYCLAVANCE is 5 mg/kg/day as a single daily dose for 30 days. Following this initial daily treatment period, the dose of CYCLAVANCE may be tapered by decreasing the frequency of dosing to every other day or twice weekly, until a minimum frequency is reached which will maintain the desired therapeutic effect. CYCLAVANCE should be given at least one hour before or two hours after a meal. If a dose is missed, the next dose should be administered (without doubling) as soon as possible but dosing should be no more frequent than once daily. The dispensing system for the 5 and 15 mL vial sizes includes a 1 mL oral dosing syringe graduated in 0.05 mL increments. To dose the dog, administer 0.05 mL of CYCLAVANCE per 2.2 lbs of body weight. The dispensing system for the 30 and 50 mL vial sizes includes both a 1 mL oral dosing syringe graduated in 0.05 mL increments, and a 3 mL oral dosing syringe graduated in 0.1 mL increments. To dose the dog, administer 0.1 mL of CYCLAVANCE per 4.4 lbs of body weight. Do not rinse or clean the oral dosing syringe between uses. (See instructions for assembling the dispensing system and preparing a dose of CYCLAVANCE.)

CONTRAINDICATIONS:

CYCLAVANCE is contraindicated for use in dogs with a history of neoplasia. Do not use in dogs with a hypersensitivity to cyclosporine.

WARNINGS:

CYCLAVANCE (cyclosporine oral solution) is a systemic immunosuppressant that may increase susceptibility to infection and the development of neoplasia.

HUMAN WARNINGS: Not for human use. Keep this and all drugs out of reach of children. For use only in dogs. Special precautions to be taken when administering CYCLAVANCE in dogs: Do not eat, drink, smoke, or use smokeless tobacco while handling CYCLAVANCE. Wear gloves during administration. Wash hands after administration. In case of accidental ingestion, seek medical advice immediately and provide the package insert or the label to the physician. People with known hypersensitivity to cyclosporine should avoid contact with CYCLAVANCE. People with known hypersensitivity to cyclosporine should avoid contact with CYCLAVANCE.

PRECAUTIONS:

The safety and effectiveness of cyclosporine has not been established in dogs less than 6 months of age or less than 4 lbs body weight. CYCLAVANCE is not for use in breeding dogs, pregnant, or lactating bitches. Exacerbation of subclinical neoplastic and infectious conditions may occur with any immunomodulation regimen. Gastrointestinal problems and gingival hyperplasia may occur at the initial recommended dose (See Animal Safety).

CYCLAVANCE may cause elevated levels of serum glucose, and should be used with caution in cases with diabetes mellitus. If signs of diabetes mellitus develop following the use of CYCLAVANCE, consideration should be given to tapering or discontinuing the dose.

CYCLAVANCE should be used with caution with drugs that affect the P-450 enzyme system. Simultaneous administration of CYCLAVANCE with drugs that suppress the P-450 enzyme system, such as azoles (e.g. ketoconazole), may lead to increased plasma levels of cyclosporine.

Since the effect of cyclosporine use on dogs with compromised renal function has not been studied, CYCLAVANCE should be used with caution in dogs with renal insufficiency.

There have been reports of convulsions in human adult and pediatric patients receiving cyclosporine, particularly in combination with high dose methylprednisolone (See Animal Safety).

Killed vaccines are recommended for dogs receiving CYCLAVANCE because the impact of cyclosporine on the immune response to modified live vaccines is unknown (See Animal Safety).

FAQ

What is Cyclavance?

Cyclavance is a 100mg/ml ciclosporin oral solution for cats and dogs with a 6-month shelf life once broached. Cyclavance allows accurate dosing to the nearest kg in one easy administration, which limits the risks and inefficiencies of under and overdosing.

What can I use Cyclavance for?

Treatment of chronic manifestations of atopic dermatitis in dogs and, in cats, symptomatic treatment of chronic allergic dermatitis.

What is the on label dose rate?

In dogs = 5mg/kg & in Cats = 7mg/kg daily. Once clinical signs are improving, the dosing frequency can be reduced to every other day or less frequently.

With or without food?

The product can be applied directly into the mouth or given with a small amount of food to ensure the whole dose is consumed.

How quickly will I see clinical results?

Usually clinical signs are improving between 4 to 8 weeks after the course has been started, but may be sooner depending on concurrent medications and allergy control.

What are the common adverse effects and how are they managed?

It is common for the oily excipient to cause some gastrointestinal upsets such as vomiting and diarrhea. They are mild and transient and generally do not require the cessation of the treatment. Other side effects are listed on the datasheet and include symptoms like lethargy and inappetence. Reducing the dose or frequency of application can control these adverse effects.

Does Cyclavance induce tumors?

While ciclosporin does not induce tumors, it does inhibit T-lymphocytes and therefore treatment with ciclosporin may lead to an increased incidence of clinically apparent malignancy due to the decrease in anti-tumor immune response. Lymphadenopathy observed on treatment with ciclosporin should be regularly monitored. There is thus a potentially increased risk of tumor progression if the tumor is already present before or occurs during the treatment with Cyclavance. This risk must be weighed against the clinical benefit.

Why has the Cyclavance gone all thick and lumpy?

A jelly-like formation may occur below 15°C, which is, however, reversible at temperatures up to 25°C without affecting the quality of the product. After first opening, Cyclavance should be stored at room temperature between 15°C and 25°C.