NexGard COMBO Topical for Cats 1.8-5.5 lbs (Purple Box)

NexGard COMBO Topical for Cats 1.8–5.5 lbs

Complete Parasite Protection in One Easy Dose

NexGard COMBO Topical for Cats 1.8–5.5 lbs is a broad-spectrum monthly parasiticide designed to protect your cat against fleas, ticks, ear mites, roundworms, hookworms, and even tapeworms—all with a single, easy-to-apply topical treatment. Powered by a triple-action formula containing esafoxolaner, eprinomectin, and praziquantel, NexGard COMBO is vet-recommended for kittens and cats weighing between 1.8 and 5.5 lbs and aged 8 weeks or older.

Unlike conventional flea treatments that only target external parasites, this advanced formula offers inside-out protection, neutralizing intestinal worms while also eliminating fleas and ticks before they can transmit deadly diseases like Bartonella, tapeworm infestations, and Lyme disease.

Prescription items are NON-RETURNABLE and NON-REFUNDABLE.

NOTE: For generic medications, the product image shown may not reflect the actual item received. Generic medications can vary in size, color, and shape between orders depending on the manufacturer. Additionally, your medication may arrive packaged in a HardyPaw Pharmacy vial.

Also Available in:

NexGard COMBO Topical for Cats 5.6-16.5 lbs

What Are the Key Benefits of NexGard COMBO for Kittens and Small Cats?

NexGard COMBO is a comprehensive monthly treatment that goes beyond just fleas:

• Triple-Action Protection:
• Esafoxolaner kills adult fleas and ticks (Ixodes, Dermacentor, Rhipicephalus species)
• Eprinomectin targets intestinal worms (roundworms and hookworms)
• Praziquantel eliminates tapeworms
• Rapid Flea Kill Time: Begins killing fleas in as little as 6 hours, preventing flea eggs from developing into adults.
• Prevention of Tick-Borne Illnesses: Helps prevent diseases like Lyme disease and Cytauxzoonosis.
• Effective Against Zoonotic Parasites: Reduces risk of parasites transferable to humans (e.g., Toxocara cati).
• Easy-to-Apply Topical Solution: One tube, once a month, with no pills or injections required.
• Vet-Approved for Small Cats & Kittens: Safe for cats as small as 1.8 lbs and as young as 8 weeks.

How Do You Use NexGard COMBO? (Directions for Use)

• Remove one single-dose tube from the packaging.
• Hold the applicator upright, twist off the cap.
• Part the hair at the base of your cat’s skull until skin is visible.
• Apply the entire content directly to the skin in one spot.

Pro Tip: Avoid bathing your cat or allowing them to get wet for 48 hours after application.

Where Should I Apply NexGard COMBO on My Cat?

For maximum absorption and safety:

• Apply between the shoulder blades at the base of the skull.
• Ensure the product is not licked by the cat or other pets.
• Part the fur until skin is visible, then squeeze the entire tube directly on the skin.

Avoid applying near the tail, limbs, or abdomen where licking is possible.

When Should I Start Using NexGard COMBO?

• Begin use as early as 8 weeks of age or when your kitten reaches 1.8 lbs.
• Apply monthly all year round, especially in warmer climates or multi-pet households.
• It is ideal for indoor cats too, as parasites can enter the home on shoes, other pets, or through screens.

What Are the Active Ingredients in NexGard COMBO?

• Esafoxolaner is a refined molecule related to afoxolaner, designed specifically for cats.
• Eprinomectin is a macrocyclic lactone effective against gastrointestinal nematodes.
• Praziquantel is a dewormer widely used for cestode control.

How Does NexGard COMBO Work Inside Your Cat’s Body?

Understanding how NexGard COMBO operates can build user trust and education.

• Once applied to the skin, esafoxolaner is absorbed into the bloodstream.
• Fleas and ticks are killed when they bite, preventing disease transmission.
• Eprinomectin and praziquantel target internal parasites by disrupting their nervous systems.
• Parasites are eliminated either through the skin or gastrointestinal system.

This systemic action provides thorough coverage without requiring ingestion.

What Are the Possible Side Effects of NexGard COMBO?

While side effects are rare, some cats may experience:

• Temporary skin irritation at the application site
• Vomiting or diarrhea
• Lethargy
• Inappetence

Note: These effects are typically mild and resolve on their own. Contact your veterinarian if symptoms persist.

What Warnings Should You Be Aware Of?

• Not for use in cats under 1.8 lbs or under 8 weeks of age
• Do not administer to dogs or other animal species
• Store at room temperature and out of reach of children
• Use caution in cats with a history of neurologic disorders

Always consult your veterinarian before beginning any parasitic treatment.

Can I Switch From Other Flea Treatments to NexGard COMBO?

Yes, but timing matters.

• Wait until your cat’s current flea/tick product has fully worn off before applying NexGard COMBO.
• Consult your vet when transitioning from oral dewormers or other topicals to prevent ingredient overlap.
• NexGard COMBO is ideal for replacing multiple medications with a single monthly dose.

Why Choose HardyPaw’s NexGard COMBO Over Others?

• HardyPaw offers fresher stock sourced directly from licensed veterinary distributors.
• We prioritize clinical transparency by listing active ingredient functions.
• Faster delivery and easy reorder options for monthly care.
• 100% coverage against both ecto- and endoparasites – rare in most treatments.

Shipping & Returns

Shipping Policy: HardyPaw offer all types of shipping options (Ground, Express, Priority, International) depending on the urgency of the product requirements. To know about our shipping policy in detail, click here.

Refund policy: If you face any issue with our product and want to return it, read our refund policy carefully.

NexGard COMBO Topical for Cats 1.8–5.5 lbs FAQs 

1. What is NexGard COMBO used for?

NexGard COMBO is used to protect cats from fleas, ticks, ear mites, roundworms, hookworms, and tapeworms in a single monthly topical application.

2. Is NexGard COMBO safe for kittens?

Yes, NexGard COMBO is approved for kittens weighing at least 1.8 lbs and aged 8 weeks or older.

3. How long does NexGard COMBO take to work?

It begins killing fleas within 6 hours and provides full protection for 30 days.

4. Can NexGard COMBO be used with other medications?

Always consult your vet. NexGard COMBO is generally safe but should not be mixed with other topical treatments unless approved.

5. Does NexGard COMBO protect against heartworm?

No, NexGard COMBO does not provide heartworm prevention. A separate heartworm medication is required.

Authority Resources for Medical Reference

• FDA – NexGard COMBO Drug Approval
• Merck Veterinary Manual – Ectoparasites
• PetMD – Praziquantel for Cats