Osphos (clodronate) Injection for Horses 60mg/mL (15 mL)

Advanced Pain Relief for Horses’ Navicular Syndrome

Product Description

OSPHOS® is a bisphosphonate injection given by veterinarians to manage lameness in horses due to navicular syndrome. This one-time treatment helps decrease bone resorption and enhances comfort in the forelimbs. Clinical studies show that many horses experience significant improvement in just two months, and many continue to benefit for up to six months. OSPHOS® offers a scientifically backed solution for horses dealing with pain and lameness.

Benefits

• Rapid Relief: Horses often show improvement in lameness within two months post-treatment.
• Long-lasting Effects: Many horses maintain reduced clinical signs for up to six months.
• Scientifically Proven: Effectiveness validated in controlled field studies with measurable outcomes.
• Veterinarian Approved: Administered under professional supervision to ensure safety and proper dosage.
• Improves Comfort: Reduces discomfort, nervousness, and pawing associated with navicular syndrome.
• Bone Health Support: Inhibits osteoclast activity to limit bone resorption without impacting overall bone density.

Ingredients

Active Ingredients

Clodronate disodium tetrahydrate 74.98 mg/mL (equivalent to 60 mg/mL clodronate disodium)

How to Use

Recommended-Dosage Chart

Dosage & Administration Instructions

• Single Dose Use: Administer a single intramuscular injection per treatment session for optimal effect.
• Divide Injections: Distribute the total dose evenly among three different injection sites to minimize discomfort.
• Maximum Volume Limit: Make sure that each injection site does not exceed 15 mL for safety and proper absorption.
• Monitor Response: Watch the horses for at least two hours post-injection for any clinical signs.
• Prescription Requirement: OSPHOS® needs a prescription and should be administered by or under the guidance of a licensed veterinarian.
• Re-administration Guidelines: If improvement decreases, re-administer every 3 to 6 months based on the return of clinical signs.

Disclaimer: This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any supplement for your pet.

Additional Information

Precautions

• Age Restriction: Not evaluated for horses less than 4 years old due to possible effects on their developing bones.
• Pregnant Mares: Should not be used in pregnant or lactating mares because of potential risks to the fetus.
• Renal Function: Avoid in horses with kidney dysfunction or those on nephrotoxic medications.
• Mineral Imbalance: Use caution in horses with electrolyte disorders, as bisphosphonates can temporarily change mineral levels.
• Human Safety: Keep away from humans; not for human consumption, and in case of accidental exposure, seek medical advice.

Possible Side Effects

• Colic and Pawing: Some horses may experience colic, pawing, or abdominal discomfort shortly after injection.
• Nervousness or Agitation: Horses may show signs of restlessness, circling, or tail twitching post-treatment.
• CNS Signs: Yawning, flehmen, head shaking, or neck writhing can occur temporarily after administration.
• Injection Site Reactions: There may be mild to moderate swelling at the injection site, which usually resolves in about 10 days.
• Laboratory Changes: Transient increases in BUN, creatinine, or potassium may occur following treatment.

Storage Information

• Temperature Management: Keep at 25°C, allowing for variations between 15°C and 30°C to ensure the drug remains stable.
• Single-Use Vial: Throw away any leftover portion after injection to avoid contamination.
• Original Packaging: Keep in original carton until use to protect from light and maintain sterility.

Shipping & Return

We offer ground, express, priority, and international delivery; see our shipping policy for details.

For return instructions or product concerns, please refer to our detailed refund policy. 

Prescription items are NON-RETURNABLE and NON-REFUNDABLE.  

Frequently Asked Questions

Q1: How does OSPHOS® help horses with navicular syndrome?

Ans: OSPHOS® functions by blocking osteoclast activity and lowering bone resorption, which enhances comfort in the forelimbs and reduces lameness. Clinical research indicates that most horses see considerable improvement within two months, and many continue to enjoy benefits for as long as six months.

Q2: What is the recommended dosage for OSPHOS®?

Ans: The recommended dosage is 1.8 mg/kg via intramuscular injection, with a maximum limit of 900 mg for each horse, distributed over three distinct sites. If clinical signs return, re-administration can happen every 3–6 months.

Q3: Can OSPHOS® be used in young or pregnant horses?

Ans: OSPHOS® is not tested on horses less than 4 years old or on pregnant or lactating mares due to potential risks to bones and fetuses. It should only be administered to adult horses under the guidance of a veterinarian.

Q4: What side effects should I monitor after treatment?

Ans: Horses can show signs like colic, nervousness, pawing, yawning, head shaking, or swelling at the injection site soon after getting the shot. Most symptoms go away in a few hours, usually with some hand walking. If there are serious reactions, a vet should be consulted.

Q5: Is OSPHOS® available without a prescription?

Ans: No. OSPHOS® is a prescription-only medication and must be administered by or on the order of a licensed veterinarian to ensure proper dosing and safety.

Clinical Researches

https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/abs/10.1002/dta.3050

https://beva.onlinelibrary.wiley.com/doi/abs/10.1111/evj.13244

https://avmajournals.avma.org/view/journals/ajvr/84/8/ajvr.23.03.0051.xml