Sileo (dexmedetomidine oromucosal) Oromucosal Gel for Dogs

Zoetis SKU: 10015193


Shipping calculated at checkout

Available Now!

3 mL
3 mL Bundle of 2
3 mL Bundle of 3

Add to Cart

Sileo (dexmedetomidine oromucosal) Oromucosal Gel for Dogs

Sileo Gel Dogs, a dexmedetomidine oromucosal gel, is the sole FDA-approved solution for dogs experiencing noise sensitivity. Your vet prescribes this medicine to calm your dog down when they are scared by loud sounds. Typical causes of noise aversion are fireworks, thunder, construction, traffic, parties, vacuuming, and smoke alarms. Sileo operates by inhibiting norepinephrine, a neurotransmitter in the brain that is comparable to adrenaline and increases feelings of anxiety.

  • Initial FDA approval for treating noise aversion in dogs
  • Relaxing without causing drowsiness, enabling typical interactions between dogs and their owners
  • Simple to use at home, as required.
  • Functions independently without requiring additional interventions or education.
  • Rapid initiation of effects
  • Encourages early action for maximum impact on the dog's quality of life
  • Remains active for a maximum of 3 hours.

Sileo Gel For Dogs Dosage

Sileo is applied to the inner lining of the mouth by placing the gel between the cheek and gums of your dog, enabling absorption through the mucous membrane. As the gel is taken in through the skin, avoid letting your dog swallow it. If the gel is ingested, it may reduce the effectiveness of the product, so avoid taking another dose for at least two hours. A dose exceeding 6 dots must be evenly split between the two sides of the mouth. When administering Sileo, it is important to wear gloves. The dosage guide is based on how much a person weighs and the corresponding number of dots. One dot is equal to 0.25 mL; 4 dots are the same as 1 mL. Check out the video above for a more in-depth explanation.

Possible Side Effects

No serious adverse reactions are attributed to the administration of dexmedetomidine oromucosal gel in dogs.

Storage Instructions

Store opened and unopened syringes in the original package at controlled room temperatures of 68° - 77°F. Use contents within 4 weeks after opening the syringe.

Prescription items are NON-RETURNABLE and NON-REFUNDABLE.


How Much Does Sileo Cost?

The cost of Sileo, a medication used to treat noise aversion in dogs, can vary depending on the retailer and location. On average, the price for a 3 ml tube of Sileo gel typically ranges from $25 to $35. Prices may vary based on factors such as the pharmacy, online retailer, or if you purchase it directly through your veterinarian. For the most accurate and up-to-date pricing, it's best to check with local pharmacies, veterinary clinics, or online pet medication suppliers.

What is Gel-Sileo for Dogs Side Effects?

Gel-Sileo, a medication used to treat noise aversion in dogs, can have side effects. While it is generally well-tolerated, some dogs may experience adverse reactions. Common side effects of sileo oromucosal gel can include:

  1. Sedation: Some dogs may become sleepy or more relaxed than usual.
  2. Vomiting: Dogs may experience nausea or vomiting after administration.
  3. Diarrhea: Gastrointestinal upset can result in loose stools.
  4. Pale Gums: Some dogs may have pale gums, which is a sign of reduced blood flow.
  5. Hypersalivation: Increased drooling or salivation may occur.
  6. Decreased Heart Rate: A slower-than-normal heart rate (bradycardia) can be observed in some dogs.

If you notice any severe side effects or if your dog shows signs of an allergic reaction (such as swelling, difficulty breathing, or extreme lethargy), contact your veterinarian immediately. Always follow your veterinarian's instructions when using Sileo and report any unusual symptoms to ensure the safety and well-being of your pet.

How long does it take for Sileo to Work?

Sileo generally begins to take effect 20 to 30 minutes after being given. The medication is specifically formulated to offer rapid alleviation for noise sensitivity in dogs, like anxiety triggered by thunderstorms or fireworks. The benefits may endure for 2 to 3 hours, aiding in soothing your dog in stressful situations. Make sure to always adhere to the dosage guidelines given by your vet to guarantee the safety and effectiveness of the medication for your pet.

What types of adverse events have been reported?

Very few adverse events have been reported with the use of Sileo. Vomiting, sedation, and/or drowsiness were infrequently reported.

Why should pet owners avoid feeding or giving treats to their dog within 15 minutes after dosing Sileo?

Avoiding food and treats 15 minutes after dosing minimizes the risk of the dog swallowing any part of the dose.

What if the dog receives more than the prescribed dose of Sileo?

Much of the excess gel may flow out of the mouth or be swallowed, which would limit the effects on the dog. In a worst-case scenario where the entire syringe (3 ml) is accidentally applied to a smaller dog and is fully absorbed, mild to moderate sedation may occur. Advise your clients to call your clinic should they give a higher-than-prescribed dose.

How should Sileo be stored?

Both new and partially used syringes of Sileo should be stored in the carton provided (protected from light) at room temperature.