Simparica for Large Dogs 88.1-132 lbs

Simparica 120mg Monthly Chew for Complete Flea and Tick Defense in Extra-Large Dogs

Product Description

Simparica (sarolaner) 120 mg is a prescription-strength, pork liver-flavored monthly chewable tablet specially formulated for extra-large dogs weighing 88.1 to 132 lbs. Powered by sarolaner, an isoxazoline-class insecticide and acaricide, it targets the nervous system of parasites to deliver fast, sustained protection. Fleas start dying off within 3 hours and ticks within 8 hours, with that level of protection holding steady without any drop-off right through the full 35 days.

Benefits

• Rapid Flea Elimination: Adult fleas begin dying off within just 3 hours of the first dose, bringing quick relief to large breeds dealing with active infestations.
• Tick Control Within 8 Hours: All six controlled tick species are tackled within 8 hours, keeping outdoor and active large dogs well covered against tick threats.
• Six-Tick Species Coverage: Kills Lone Star, Gulf Coast, American Dog, Black-legged, Brown Dog, and Asian Longhorned ticks with a single monthly dose.
• Deer Tick Kill in 12 Hours: Shown to eliminate over 98% of existing deer tick infestations within 12 hours, well before Lyme disease transmission typically occurs.
• FDA-Approved Lyme Prevention: Approved to block Borrelia burgdorferi infections by killing deer ticks, providing an important layer of disease prevention for large dogs.
• Oral Waterproof Protection: As an oral treatment, bathing and swimming do not reduce its effectiveness, making it ideal for large, active, and water-loving breeds.
• Sustained 35-Day Potency: Unlike some treatments that weaken over time, Simparica maintains full effectiveness right through to day 35 without any drop in potency.

Ingredients

Active Ingredients

Sarolaner 120 mg per tablet

How to Use

Dosage & Administration Instructions

• Prescription Requirement: Simparica is federally restricted to use by or on the order of a licensed veterinarian; always have a valid prescription before purchasing or administering.
• Correct Dose for Extra-Large Dogs: Administer one 120 mg chewable tablet orally once every 28 to 30 days to dogs weighing between 88.1 and 132 lbs.
• Flexible Feeding Options: Offer the chew by hand, mixed into food, or like a standard oral tablet; Simparica can be given with or without food.
• Confirm Complete Consumption: Observe your dog for a few minutes after dosing to verify the entire tablet has been swallowed and no portion has been dropped or refused.
• Dogs Over 132 lbs: For dogs exceeding 132 lbs, administer an appropriate combination of Simparica tablets to cover the dog's total body weight as directed by your veterinarian.
• Missed Dose Protocol: On a missed dose, administer it right away and simply carry on with the usual monthly dosing from that point.
• Year-Round Monthly Use: Begin treatment at any time of year and continue every 30 days without interruption for reliable, unbroken flea and tick protection.

Disclaimer: This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any supplement for your pet.

Additional Information

Precautions

• Age Restriction: Simparica is only approved for dogs 6 months of age and older; do not use in puppies younger than this regardless of body weight.
• Seizure and Neurological History: Use with extra caution in dogs with a known history of seizures or neurological disorders and only under close veterinary supervision.
• Reproductive Use Not Evaluated: How this product affects breeding, pregnant, or nursing dogs is still unknown, so always check with your vet beforehand.
• Strictly for Dogs Only: Simparica is formulated exclusively for dogs; it must never be administered to cats or any other animal species under any circumstances.
• Prevent Accidental Ingestion: Keep this product tucked away somewhere all pets cannot reach, as accidental ingestion or overdose remains a real risk.
• Children Must Not Access: Keep Simparica and all veterinary medications completely out of reach of children at all times.

Possible Side Effects

• Vomiting: The most frequently reported adverse reaction in clinical trials; typically mild and short-lived following administration of the monthly dose.
• Diarrhea: Loose stools, occasionally with blood, have been noted in a small percentage of dogs after receiving Simparica during clinical studies.
• Lethargy: Some dogs may temporarily appear tired or less active for a short period following each monthly dose of Simparica.
• Tremors and Unsteadiness: Muscle tremors and ataxia are reported post-approval adverse events; contact your veterinarian promptly if these signs appear after dosing.
• Seizures: Seizures have been reported in dogs on isoxazoline-class products, including those with no prior seizure history; seek immediate veterinary attention if this occurs.
• Reduced Appetite and Hypersalivation: Anorexia and excessive drooling are among the post-approval adverse events reported by dog owners and veterinary professionals after use.

Storage Information

• Store at or Below 30°C: Keep this product at or below 30°C (86°F), though brief exposure to temperatures as high as 40°C (104°F) will not compromise its quality or effectiveness.
• Secure Away from Pets: Tuck the tablets away somewhere completely out of any pet's reach to avoid the risk of accidental self-dosing or overdose.
• Keep Away from Children: As with all prescription pet medications, always store Simparica where children have no access to it.

Shipping & Return

We offer ground, express, and priority delivery; see our shipping policy for details.

For return instructions or product concerns, please refer to our detailed refund policy.

Prescription items are NON-RETURNABLE and NON-REFUNDABLE.

Frequently Asked Questions

Q1: What is Simparica 120mg brown pack used for in extra-large dogs?

Ans: Simparica 120 mg is a monthly prescription flea and tick chewable for extra-large dogs weighing 88.1 to 132 lbs. It kills adult fleas, prevents re-infestation, controls six tick species, and is FDA-approved to help block Lyme disease-causing infections in eligible dogs.

Q2: How fast does Simparica sarolaner chew work against deer ticks on large dogs?

Ans: Simparica wipes out more than 98% of deer tick infestations in as little as 12 hours after a single dose. That matters because deer ticks generally need anywhere from 24 - 48 hours to pass on Lyme disease, making that rapid action especially valuable for large dogs that spend a lot of time outdoors.

Q3: Can Simparica extra-large dog chew be given during bath time or swimming?

Ans: Since Simparica is an oral medication that gets absorbed into the bloodstream, water simply plays no role in how well it works. Whether your dog loves swimming, needs regular baths, or spends time outdoors in the rain, the protection stays just as strong — making it a great fit for active and water-loving breeds.

Q4: What should I do if my extra-large dog misses a monthly Simparica dose?

Ans: On a missed dose, go ahead and give the 120 mg tablet when you notice and pick up the regular monthly schedule from that point. Avoid giving two doses at once to make up for the missed one. When in doubt about the timing or your dog's current health, check in with your vet before starting back up.

Q5: Is Simparica flea and tick tablet safe for extra-large dogs with a seizure history?

Ans: Simparica belongs to the isoxazoline class, which has been linked to neurological signs including tremors, unsteadiness, and seizures in some dogs, even those without prior seizure history. Dogs with a known seizure or neurological disorder history should only receive this medication under direct veterinary guidance.

Clinical Research

American Veterinary Medical Association (AVMA) – Flea and Tick Control in Pets

FDA – Safe Use of Isoxazoline Flea and Tick Products

Companion Animal Parasite Council (CAPC) – Tick-Borne Diseases in Dogs