Simparica Trio for Puppies 2.8-5.5 lbs

Triple-Action Monthly Chewable Parasite Protection for Puppies 2.8–5.5 lbs (Gold Box)

Product Description

Simparica Trio for Puppies 2.8–5.5 lbs is the number one veterinarian-prescribed combination parasiticide for dogs, formulated as a once-monthly, pork liver-flavored chewable that covers heartworm disease, six tick types, fleas, flea tapeworms, roundworms, and hookworms in one dose. Each Gold Box tablet contains sarolaner, moxidectin, and pyrantel, calibrated for puppies weighing 2.8 to 5.5 lbs and safe for pups as young as 8 weeks.

Variants

Simparica Trio Chewable Tablet is available in the following options:

• Simparica Trio Chewable Tablets for Dogs 2.8-5.5.0 lbs
• Simparica Trio Chewable Tablets for Dogs 5.6-11.0 lbs
  
• Simparica Trio Chewable Tablets for Dogs 11.1-22.0 lbs
  
• Simparica Trio Chewable Tablets for Dogs 22.1-44.0 lbs
  
• Simparica Trio Chewable Tablets for Dogs 44.1-88.0 lbs
  
• Simparica Trio Chewable Tablets for Dogs 88.1-132.0 lbs

Benefits

• Triple Protection in One Monthly Chew: Guards against heartworm disease, ticks and fleas, and intestinal worms, including roundworms and hookworms, all in a single monthly tablet.
• 100% Heartworm Protection: One monthly dose delivered 100% protection against heartworm disease caused by Dirofilaria immitis in studies supporting FDA approval.
• Kills 6 Types of Ticks: The only combination preventative proven to kill six tick types, including Gulf Coast, Deer, American Dog, Lone Star, Brown Dog, and Asian Longhorned ticks.
• FDA-Approved to Prevent Lyme Infections: The only combination chewable FDA-approved to prevent Borrelia burgdorferi infections that may lead to Lyme disease by killing deer ticks.
• Fast-Acting Flea and Tick Kill: Each dose begins killing fleas in 4 hours and deer ticks in 8 hours per study results.
• Prevents Flea Infestations: By targeting fleas before they can lay eggs, this chew stops home infestations from ever getting started.
• Prevents Flea Tapeworm Infections (FDA-Approved): The only canine combination parasiticide FDA-approved to prevent flea tapeworm infections by killing vector fleas before transmission occurs.
• Treats and Controls Roundworms and Hookworms: Eliminates immature and adult roundworms and hookworms, including key Ancylostoma caninum and Toxocara canis life stages.
• Safe for Puppies 8 Weeks and Older: Safety has been established in puppies from 8 weeks old and 2.8 lbs, making it a great early starter.
• Highly Palatable Pork Liver Flavor: Studies show 9 out of 10 dogs voluntarily consumed Simparica Trio, making monthly dosing stress-free for pets and owners alike.
• Give With or Without Food: Can be given any time of day with or without a meal, with no impact on effectiveness or palatability whatsoever.
• 100% Satisfaction Guarantee: Backed by Zoetis' 100% satisfaction guarantee; if not satisfied for any reason, Zoetis will provide a replacement or full refund.

Ingredients

Active Ingredients (Per Tablet — Gold Box, 2.8–5.5 lbs)

Inactive Ingredients

Colloidal silicon dioxide, crospovidone, hypromellose, iron oxide yellow, lactose monohydrate, macrogol 3350, microcrystalline cellulose, natural pork liver flavor, povidone, silica colloidal anhydrous, soy lecithin

How to Use

Directions for Use

• Prescription Required: A valid veterinarian authorization is needed before purchasing or using Simparica Trio for your puppy.
• Heartworm Test Required Before Starting: Have your veterinarian test the dog for existing heartworm infections before giving the first dose of Simparica Trio.
• Once Monthly Administration: Give one chewable tablet orally once every month, with or without food, on the same date each month for consistent protection.
• Minimum Recommended Dose: Each dose delivers at least 0.54 mg/lb sarolaner, 0.011 mg/lb moxidectin, and 2.27 mg/lb pyrantel pamoate per body weight.
• Ensure Full Dose is Consumed: Confirm the dog finishes the entire chew; if not fully eaten, offer the remainder or give a fresh tablet right away.
• Do Not Split the Tablet: Simparica Trio chewables are not scored and cannot be divided; always give the complete tablet matched to the dog's current weight.
• Missed Dose Instructions: Replace any missed or vomited dose right away and pick up the monthly routine from there.
• Year-Round Administration: Parasites are active all year, so give Simparica Trio every month without seasonal breaks for continuous and reliable protection.
• Correct Weight-Based Tablet Selection: Always check the puppy's current weight before selecting the right tablet; use the Gold Box only for puppies weighing 2.8–5.5 lbs.

Disclaimer: This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any medication for your pet.

Additional Information

Precautions

• Prescription Only: Simparica Trio is available by prescription only and must not be used without prior veterinary assessment and authorization.
• Use with Caution in Dogs with Seizure History: Sarolaner belongs to the isoxazoline class, which has been linked to tremors, ataxia, and seizures in dogs with or without a prior neurologic history.
• Puppy Use Restrictions: This product is not suitable for puppies below 8 weeks of age or under 2.8 lbs.
• Reproductive Status Caution: This product has not been tested in breeding, pregnant, or lactating dogs; always keep your vet informed.
• Do Not Use in Cats: Simparica Trio is formulated exclusively for dogs and must never be given to cats under any circumstances.
• No Unsupervised Combinations: Simparica Trio has not been studied with other parasite medications; get vet approval before mixing any treatments.
• Keep Out of Reach of Children and Pets: Store all tablets in their original packaging somewhere children and other pets cannot access them.

Possible Side Effects

• Vomiting and Diarrhea: The most common reactions reported in trials were vomiting and diarrhea; contact your vet if symptoms persist or get worse after dosing.
• Neurologic Adverse Reactions: Tremors, ataxia, and seizures have been reported with isoxazoline-class drugs, including sarolaner; contact your vet right away if any neurologic signs appear.
• Lethargy and Decreased Appetite: Some dogs may show brief lethargy or reduced appetite after dosing; reach out to your vet if these signs last or seem severe.
• Overdose: Contact your veterinarian or nearest emergency animal clinic immediately if an overdose is suspected at any point.

Storage Information

• Store at or Below Room Temperature: Keep tablets at or below 77°F (25°C) in their original packaging to preserve potency and stability over time.
• Keep in Original Packaging: Leave tablets in their original blister packs until use to protect them from moisture and physical damage.
• Keep Away from Children and Pets: Store all medications securely somewhere children and other pets cannot reach or access them.

Shipping & Return

We offer ground, express, and priority delivery; see our shipping policy for details.

For return instructions or product concerns, please refer to our detailed refund policy.

Prescription items are NON-RETURNABLE and NON-REFUNDABLE.

Frequently Asked Questions

Q1: What does Simparica Trio for Puppies 2.8–5.5 lbs protect against?

Ans: The Gold Box covers heartworm disease, six tick types, including Gulf Coast, Deer, American Dog, Lone Star, Brown Dog, and Asian Longhorned, plus fleas, flea tapeworms, roundworms, and hookworms. It is the only combination chewable with FDA approval covering all of these indications in one monthly dose.

Q2: How young can a puppy be when starting Simparica Trio?

Ans: Puppies from 8 weeks old and 2.8 lbs can safely start on this monthly chewable. The Gold Box is made for the 2.8 to 5.5 lb weight range. A quick vet check before starting any new puppy on a prescription product is always a smart move.

Q3: Does Simparica Trio require a veterinarian's prescription?

Ans: Yes, Simparica Trio is prescription-only. A valid veterinarian authorization is required before purchase, and your vet will also test for existing heartworm infections before the first dose to confirm the medication is safe to start for your dog.

Q4: How quickly does Simparica Trio start killing fleas and ticks on puppies?

Ans: Fleas start dying within 4 hours of each dose, with full flea kill confirmed at the 8-hour mark in studies. Deer ticks are tackled within 8 hours too, cutting down tick-borne disease risk and shutting down flea infestations before eggs are ever laid.

Q5: What should I do if my puppy misses a dose of Simparica Trio?

Ans: Give the missed dose right away and then carry on with the regular monthly schedule from that point. If the tablet is vomited or spat out, offer a fresh one immediately and continue as normal. A monthly reminder app can help keep dosing on track.