Bravecto vs Credelio

Bravecto vs Credelio - Which Flea and Tick Treatment Is Right for Your Dog?

Edward Simmons

How do you decide between two trusted flea and tick treatments like Bravecto and Credelio in 2025?

Both are prescription medications that belong to the isoxazoline class—a group of parasiticides that target the nervous system of fleas and ticks to kill them quickly before they can transmit diseases like Lyme or ehrlichiosis. These medications break the flea life cycle and are formulated for convenient, chewable dosing.

📌 TL;DR – Bravecto vs Credelio (2025)

  • Main Difference: Bravecto lasts 12 weeks per dose; Credelio works monthly.
  • Best For Heavy Infestations: Bravecto—faster kill rate and longer residual action.
  • Small Dog Friendly: Credelio—smaller chew size, safe for puppies from 8 weeks.
  • Dosing Style: Bravecto = quarterly; Credelio = monthly.
  • Safety Profile: Both are FDA-approved with similar mild side effects.
  • Price Range:
    • Bravecto: $25.99–$80.99 (based on weight & form)
    • Credelio: $20.58–$36.98 per chew
  • Switching Safe? Yes, but only after current dose cycle ends and with vet approval.
  • Use with Heartworm Meds? Yes, safe to combine with vet-recommended preventatives.

Image source

Did you know that the isoxazoline class, trusted for its rapid flea and tick elimination, isn’t just popular among vets. In fact, the North American isoxazoline market is projected to hit $5.6 billion by 2030, growing at 18.1% annually, reflecting its widespread adoption by pet owners. (Source)

Bravecto and Credelio both offer oral tablets, but they differ in duration of action, cost, and species coverage. Bravecto protects for up to 12 weeks, while Credelio is a monthly treatment. Understanding their differences helps you choose the best option for your dog’s lifestyle, age, and exposure to parasites.

Other vet-approved options like NexGard, Simparica Trio, and Frontline Plus also serve similar purposes—but this guide focuses specifically on helping you choose between Bravecto and Credelio. Let’s get stated!

What Are Bravecto and Credelio Used For?

Starting with a clear understanding of both of the medications:

What is Bravecto?

Bravecto Topical Solution for Cats 2.6-6.2 lbs

Bravecto is a prescription flea and tick treatment made by Merck Animal Health. It protects dogs for up to 12 weeks with a single dose. Bravecto contains the active ingredient fluralaner, which kills parasites by overstimulating their nervous system. Bravecto is part of the isoxazoline class and is available as a chewable for dogs and a topical solution for both dogs and cats. 

What Is Credelio?

Credelio for Dogs 50.1-100 lbs 3 tablet

Credelio is a monthly flea and tick medication developed by Elanco Animal Health. It provides 30 days of protection. Credelio's active ingredient is lotilaner, which targets fleas and ticks by interfering with their nerve activity. Credelio is designed exclusively for dogs, with chewable tablets available in weight-specific doses. It starts killing fleas within 4 hours and ticks within 8–12 hours.

Now that you know who manufactures Bravecto and Credelio and how each works, let’s look at how they compare side-by-side, covering ingredients, protection duration, safety, and other key features in a quick-reference table.

What are the Differences Between Bravecto and Credelio?

The main difference is that Bravecto provides up to 12 weeks of protection per dose, while Credelio offers monthly coverage. Bravecto is ideal for longer-lasting parasite control with fewer doses, while Credelio suits pet owners who prefer a flexible, monthly routine.

Let’s understand other differences in the infographic below:

Bravecto & Credelio Difference

Now that we’ve covered the side-by-side differences, let’s explore how these treatments perform in the real world, specifically their speed of action, coverage spectrum, and effectiveness against different tick species.

Which Kills Fleas & Ticks Faster - Bravecto or Credelio?

  • Bravecto starts killing fleas within 2 hours, which is slightly faster than Credelio, as Credelio takes about 4 hours. 
  • For ticks, Bravecto generally reaches full efficacy within 12 hours, while Credelio ranges between 8 to 12 hours, depending on the tick species.

These slight differences may matter if your pet already has a visible infestation or is prone to allergic reactions caused by flea bites, such as flea allergy dermatitis (FAD).

What Tick Species Are Covered by Bravecto and Credelio?

Both Bravecto and Credelio are effective against major U.S. tick species, including:

  • American dog tick
  • Brown dog tick
  • Black-legged (deer) tick
  • Lone Star tick

However, clinical trials show Bravecto maintains tick-killing efficacy slightly longer, especially when approaching the end of the treatment cycle. This can be beneficial in high-risk regions or during peak tick season.

Bravecto or Credelio - Which Works Better for Heavy Infestations?

Bravecto may be more effective for heavy infestations because it maintains therapeutic blood levels longer, ensuring sustained kill rates even as new parasites appear.

While speed and coverage are vital, safety always comes first.

Let’s now take a closer look at how both medications perform when it comes to side effects, risk factors, and special breed considerations.

Bravecto and Credelio Side Effects - Are These Safe for All Dogs?

Both Bravecto and Credelio are FDA-approved and generally considered safe when used as directed. 

What Side Effects Can Bravecto Cause in Dogs?

Bravecto may cause vomiting, diarrhea, decreased appetite, lethargy, increased thirst, and flatulence (less common). 

In rare cases, neurological symptoms like tremors or ataxia (loss of coordination) have been reported, mostly in dogs with pre-existing seizure conditions.

What are the Side Effects with Credelio for Dogs?

Credelio is also considered safe but can cause vomiting, diarrhea, weight loss (in prolonged use), excessive drooling, skin irritation, or itching in rare cases.

Like Bravecto, Credelio may trigger neurological symptoms in sensitive dogs, especially those with a seizure history.

Are There Safety Concerns for Specific Breeds or Ages?

Dogs with a known MDR1 gene mutation—more common in herding breeds like Collies and Australian Shepherds—may be more sensitive to isoxazoline-based treatments. While neither Bravecto nor Credelio is contraindicated for these dogs, extra caution is advised.

Puppies must meet minimum age and weight thresholds:

  • Bravecto: ≥6 months and ≥4.4 lbs
  • Credelio: ≥8 weeks and ≥4.4 lbs

Senior dogs and those with a history of seizures or neurological conditions should be evaluated by a veterinarian before starting either treatment.

How Should Pet Owners Handle Adverse Reactions of Bravecto and Credelio?

If your dog shows unusual symptoms after taking Bravecto and Credelio, contact your veterinarian immediately. 

Adverse reactions can also be reported to the FDA's Center for Veterinary Medicine (CVM) or directly to the manufacturer for pharmacovigilance tracking.

Now that we’ve covered safety, let’s talk about practicality—how easy each medication is to give, how well dogs accept the chews, and what can affect treatment compliance.

How Easy Are Bravecto and Credelio to Administer?

Both Bravecto and Credelio are given once every 12 weeks, while Credelio is given monthly, which may be easier to remember for some pet owners.

Which Treatment Is More Palatable for Dogs?

Both Bravecto and Credelio come as flavored chewable tablets, which makes them easier to administer than liquid drops or topical sprays. However, individual preference can vary. 

Some dogs take Bravecto readily, while others may prefer the smaller size and texture of Credelio.

Veterinary feedback suggests Credelio tends to be better accepted by small-breed dogs, especially those who are more sensitive to chew size or taste. If your dog is a known picky eater, testing palatability may be worth discussing with your vet.

What Are Common Mistakes to Avoid During Administration?

Even with chewables, mistakes can happen:

  • Giving medication without food can reduce absorption (especially with Credelio).
  • Splitting or crushing the tablet may alter release timing.
  • Assuming coverage is still active past the dose window.

Always read the package insert and ask your veterinarian about correct administration procedures. Using digital reminders or auto-refill plans can help maintain consistent coverage.

Now that we’ve looked at ease of use, let’s explore another big factor - cost and access. How do Bravecto and Credelio compare when it comes to pricing, availability, and value over time?

With global spending on flea, tick, and heartworm products projected to grow to $12.75 billion by 2033, it's clear that consistent parasite prevention is now a year-round priority for pet owners worldwide.(Source)

Bravecto and Credelio Pricing - Which is More Budget-friendly?

Credelio costs less per dose, but Bravecto lasts longer. If you're looking for fewer treatments per year, Bravecto may be more cost-effective overall.

How Much Does Bravecto Cost?

The average cost of Bravecto is between $25.99 and $80.99. It may vary depending on your dog’s weight and whether you choose a monthly chew, a 12-week chewable, or a topical solution.

Bravecto Chewable Tablets (12-Week Protection):

Bravecto Monthly Chews (1-Month Protection):

Bravecto Topical Solutions (12-Week Protection):

[Note: Actual pricing may vary over time. Please check the product page for the most up-to-date pricing information.]

How Much Does Credelio Cost?

The average cost of Credelio ranges from $21 to $37, depending on your pet’s weight, the specific formulation, and whether it’s for dogs or cats. 

Credelio is available as a monthly chewable tablet and includes a “Quattro” formulation for broader parasite protection in dogs.

Credelio Chewable Tablets for Dogs (Lotilaner):

Credelio Quattro Flavored Chewable Tablets (Broader Protection for Dogs):

Credelio for Cats (Lotilaner)

[Note: Actual pricing may vary over time. Please check the product page for the most up-to-date pricing information.]

While Credelio may seem more affordable per tablet, Bravecto’s extended protection often balances out the cost over time, especially for dogs who need fewer doses annually. 

Ultimately, the better value depends on your pet’s weight, your dosing preferences, and how consistent you are with monthly treatments. 

Both options are competitively priced on HardyPaw, making it easy for pet parents to choose what fits their budget without compromising protection.

fter weighing cost and coverage, some pet parents may wonder—what if the product they’re using isn’t the right fit long term? 

Whether it’s due to convenience, effectiveness, or your dog’s unique needs, switching from Credelio to Bravecto (or vice versa) is a common consideration. 

Here’s what you need to know before making the move.

Is It Safe to Switch Between Credelio and Bravecto?

Yes, switching between Credelio and Bravecto is generally considered safe, as both belong to the isoxazoline class of flea and tick medications. These drugs have compatible mechanisms of action, targeting the parasite's nervous system through selective inhibition without overlapping toxic effects.

Do I Need a Waiting Period Between Switches?

In most cases, no washout period is needed when transitioning between Bravecto and Credelio. However, it’s important to align the switch with the end of your pet’s current dosing cycle. For example:

  • If your dog is due for their next Credelio dose, you can begin Bravecto immediately.
  • If switching from Bravecto to Credelio, wait until 12 weeks post-Bravecto dose before starting Credelio.

When Is Switching a Good Idea?

You might consider switching if:

  • You need longer or shorter protection intervals
  • Your pet has a palatability issue with one brand
  • There’s a regional tick species better addressed by a specific treatment
  • You’re simplifying scheduling with other meds (e.g., monthly heartworm pills)

Always Consult Your Veterinarian before Switching

Although both treatments are broadly safe and compatible, your vet can assess breed sensitivities, age, medical history, and any concurrent medications to recommend the safest switch timing.

If you're considering switching flea and tick treatments, it's equally important to know how they interact with other parasite preventatives your pet may already be on, especially heartworm medications. 

Let’s explore whether Bravecto or Credelio can be safely combined with these essential treatments.

Are Bravecto and Credelio Safe to Use with Heartworm Medications?

Yes, both Bravecto and Credelio can safely be used alongside heartworm preventatives such as Heartgard Plus, Interceptor Plus, or Simparica Trio (which already includes flea, tick, and heartworm protection). 

These medications work through different mechanisms and target different types of parasites, making a combination both effective and common in veterinary protocols.

However, depending on your pet’s specific conditions, it is advised to ask your veterinarian before combining any medicine with Bravecto and Credelio.

Can I Use Bravecto and Credelio Alongside Dewormers or Other Internal Parasite Treatments?

If your dog is being treated for tapeworms, roundworms, or hookworms with medications like Drontal, Panacur, or Pyrantel Pamoate, it’s generally safe to administer Bravecto or Credelio concurrently. However, always consult your veterinarian if your pet is undergoing intensive parasite control or shows signs of gastrointestinal sensitivity.

Can I Give Flea And Heartworm Meds on the Same Day?

It’s safe, but spacing them out by a day or two can make it easier to monitor your dog’s response, or ask your vet for the best advice depending on your pet’s condition..

Final Verdict: Should You Choose Bravecto or Credelio in 2025?

After comparing Bravecto vs Credelio across coverage, safety, ease of use, pricing, and compatibility, it’s clear that both offer trusted protection, but the best pick depends on your dog’s lifestyle, health profile, and your dosing habits.

Here’s a quick decision guide to help you choose confidently:

✅ Choose Bravecto if:

  • You want fewer treatments per year (12-week dosing)
  • You prefer topical or long-lasting chewables
  • Your dog is large, active, or outdoors often
  • You live in a tick-endemic region year-round
  • You struggle with monthly compliance

✅ Choose Credelio if:

  • You prefer monthly flexibility and small chewables
  • Your dog is small, picky, or has food sensitivities
  • You already give monthly heartworm meds
  • You want tighter monthly health monitoring
  • You plan to rotate treatments seasonally

Still Deciding?

HardyPaw gives you access to Bravecto, Credelio, NexGard, Simparica Trio, and more—all in one vet-backed, easy-to-navigate shop.
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👉Browse flea and tick protection now at HardyPaw.com

Bravecto vs Credelio FAQs

Do Bravecto or Credelio protect against ear mites or mange?

Bravecto provides off-label protection against certain types of mange, like sarcoptic mange, while Credelio is not labeled for mite control. Neither is FDA-approved specifically for ear mites. Use vet-recommended treatments like Revolution for mites.

Is Bravecto or Credelio better for dogs with food allergies?

Bravecto and Credelio both contain flavoring agents that could trigger sensitivities in dogs with food allergies. Consult your vet to evaluate inactive ingredients and consider a topical alternative if food-based triggers are a concern.

Can I use Bravecto or Credelio year-round?

Yes, both Bravecto and Credelio are safe for year-round use and recommended by veterinarians to prevent re-infestation and protect against ticks that may be active in cooler months.

Do Bravecto or Credelio protect my home environment from fleas?

No, these medications only protect the treated pet. They do not kill fleas in the home or yard. Use environmental flea sprays, vacuuming, and laundry routines to fully eliminate infestations.

How do Bravecto and Credelio interact with vaccinations or other treatments?

There are no known interactions between Bravecto or Credelio and routine vaccines or most treatments. Administering them on the same day is generally safe, but always confirm with your veterinarian.

Are there generic versions of Bravecto or Credelio available?

No, there are currently no FDA-approved generic equivalents for Bravecto or Credelio. Always purchase from authorized sellers like HardyPaw to ensure product authenticity and effectiveness.

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