Cyclavance (cyclosporine) Oral Solution For Dogs - USP Modified 100 mg/mL

Effective Atopic Dermatitis Relief Oral Solution for Dogs

Product Description

CYCLAVANCE is a veterinary prescription oral cyclosporine solution that helps control atopic dermatitis in dogs. It does this by targeting the immune response that causes itching and inflammation. Its microemulsion formulation supports consistent absorption, which helps reduce scratching, skin lesions, and discomfort. It provides a steroid-free option for long-term allergy management under veterinary supervision. 

Benefits

• Targets Immune Response: Selectively targets immune cells involved in allergic reactions, which lowers inflammation and itching in affected dogs.
• Reduces Itching Signs: Helps control scratching, licking, and chewing behaviors linked to canine atopic dermatitis, which improves comfort.
• Steroid-Free Therapy: Offers an option to corticosteroids or antihistamines and effectively manages chronic allergic skin disease.
• Flexible Dosing Schedule: Initial daily dosing can be reduced to less frequent use once clinical improvement is seen.
• Clinically Proven Results: Studies demonstrated significant improvement in pruritus and skin lesion severity within the first month of therapy.

Variants

15 mL vial
50 mL vial

Ingredients

Cyclosporine (USP Modified) 100 mg/mL

How to Use

Recommended-Dosage Chart

Dosage & Administration Instructions

• Veterinary Prescription Only: Federal law limits this medication to use by, or on the order of, a licensed veterinarian.
• Initial Daily Dose: Give 5 mg/kg once daily for 30 days before reducing the frequency based on clinical response.
• Give Before Meals: Administer at least one hour before or two hours after feeding for the best absorption and effectiveness.
• Tapering Schedule: After improvement, you can reduce the dosing frequency to every other day or twice a week as directed by the veterinarian.
• Missed Dose Instruction: If a dose is missed, give it as soon as possible without doubling or exceeding the once-daily dose.
• Syringe Handling: Do not rinse or clean the oral dosing syringe between uses to keep dosing accuracy.

Disclaimer: This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any supplement for your pet.

Additional Information

Precautions

• Immune Suppression Risk: As a systemic immunosuppressant, treatment may increase susceptibility to infections and the potential development of neoplasia.
• Young Dog Safety: Safety has not been established in dogs under six months of age or below four pounds body weight.
• Breeding Restrictions: Not recommended for breeding, pregnant, or lactating dogs due to insufficient safety data.
• Diabetes Caution: Use carefully in diabetic dogs since cyclosporine can increase blood glucose levels.
• Drug Interactions: Using this drug with other medications that affect the cytochrome P450 enzyme system may change cyclosporine blood levels.
• Renal Conditions: Be cautious when using in dogs with weak kidney function because the effects in kidney insufficiency are not fully studied.

Possible Side Effects

• Digestive Upset: Vomiting and diarrhea are the most commonly reported side effects, often resolving with continued treatment or dose adjustments.
• Reduced Appetite: Some dogs may experience anorexia, weight loss, or lethargy during therapy, requiring veterinary monitoring.
• Gum Changes: Gingival hyperplasia and swollen gums have been reported, often improving after dose reduction.
• Infection Risk: Increased susceptibility to infections such as otitis externa or urinary tract infections may occur.
• Neurological Events: Rare cases of seizures or tremors have been reported in dogs receiving cyclosporine therapy.

Storage Information

• Room Temperature Storage: Store in the original container at 68°F to 86°F (20°C to 30°C).
• Avoid Refrigeration: Do not refrigerate because precipitation may occur if stored below the recommended temperature range.
• Use After Opening: Once opened, contents should be used within 12 weeks for safety and effectiveness.
• Keep Secure: Keep out of reach of children and store medication and dosing syringe safely after each use.

Shipping & Return 

We offer ground, express, priority, and international delivery; see our shipping policy for details. 

For return instructions or product concerns, please refer to our detailed refund policy.  

Prescription items are NON-RETURNABLE and NON-REFUNDABLE.

Frequently Asked Questions

Q1: What is CYCLAVANCE used for in dogs?

Ans: CYCLAVANCE is prescribed to control atopic dermatitis in dogs weighing at least 4 lbs by reducing immune-related inflammation and itching. It helps manage symptoms such as scratching, licking, and skin lesions caused by environmental allergens. Treatment should always be supervised by a licensed veterinarian.

Q2: How long does CYCLAVANCE take to work in dogs?

Ans: Improvement is usually seen within 30 days of starting daily therapy. Once symptoms are under control, veterinarians may lower the dosing frequency to keep it effective. Response time can differ among dogs, so ongoing veterinary monitoring and dose adjustments are important for the best long-term management.

Q3: How should CYCLAVANCE be given to dogs?

Ans: CYCLAVANCE should be given by mouth using the provided dosing syringe at least one hour before or two hours after meals. Owners should not change the dosing schedule without asking a vet to ensure safe and effective treatment.

Q4: What are the most common side effects of CYCLAVANCE?

Ans: The most common side effects are vomiting and diarrhea. These usually improve with ongoing use or changes in dosage. Some other potential effects include lethargy, reduced appetite, swollen gums, and infections. Consult a veterinarian if any worrisome symptoms arise during treatment.

Q5: Can CYCLAVANCE be used with other medications?

Ans: CYCLAVANCE may interact with medications that affect the cytochrome P450 enzyme system, including certain antifungals like ketoconazole. Owners should inform veterinarians about all medications and supplements their dog receives to avoid interactions and ensure safe concurrent use when necessary.

Clinical Research:

• https://www.proquest.com/openview/cd41b8a7de963f0f6cb5b8c5c8ee48c0/1?pq-origsite=gscholar&cbl=18750&diss=y
• https://link.springer.com/article/10.1186/s12917-016-0669-9